Evidence map›Paper›PMID 27110598›Full record

ArticleImmunotherapy (Los Angeles, Calif.)2015

Can We Repurpose FDA-Approved Alefacept to Diminish the HIV Reservoir?

Asifa Zaidi, Qinglai Meng, Daniel Popkin

Open access · greenAbstract read
In one paragraph

Article in Immunotherapy (Los Angeles, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Asifa ZaidiDepartment of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Qinglai MengDepartment of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Daniel PopkinDepartment of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
University School · USCase Western Reserve University · US

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
NIAID NIH HHS P30 AI027767NIAMS NIH HHS P30 AR039750
6 · The paper itself

Abstract

Current anti-retroviral treatment (ART) for HIV is effective in maintaining HIV at undetectable levels. However, cessation of ART results in immediate and brisk rebound of viremia to high levels. This rebound is driven by an HIV reservoir mainly enriched in memory CD4

Indexed as

ADCCAlefaceptCD4+ T cellsHIV reservoirNK cells

Identifiers

PMID27110598
PMCPMC4841618
OpenAlexW2405289417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.