Evidence map›Paper›PMID 27110574›Full record

ReviewJournal of immunology research2016

Dendritic Cells and Their Multiple Roles during Malaria Infection.

Kelly N S Amorim, Daniele C G Chagas, Fernando B Sulczewski, Silvia B Boscardin

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Frontiers in oncology · 2023
    Article
  3. Journal of inflammation research · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Monocyte-derived dendritic cells in malaria.Current opinion in microbiology · 2019
    Review
  11. Article
  12. Article
  13. Infectious Sporozoites ofFrontiers in immunology · 2018
    Article
  14. Review
  15. Response toFrontiers in microbiology · 2017
    Article
  16. Review
  17. Article
  18. IL-4Rα signaling by CD8αThe Journal of biological chemistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelly N S AmorimLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, Brazil.
Daniele C G ChagasLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, Brazil.
Fernando B SulczewskiLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, Brazil.
Silvia B BoscardinLaboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, Brazil; National Institute for Science and Technology in Vaccines, 31270-910 Belo Horizonte, MG, Brazil.ORCID 0000-0002-7845-7110
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial components as well as inflammation and on a very efficient machinery for antigen presentation. In this way, DCs sense the presence of a myriad of pathogens, including Plasmodium spp., the causative agent of malaria. Despite many efforts to control this infection, malaria is still responsible for high rates of morbidity and mortality. Different groups have shown that DCs act during Plasmodium infection, and data suggest that the phenotypically distinct DCs subsets are key factors in the regulation of immunity during infection. In this review, we will discuss the importance of DCs for the induction of immunity against the different stages of Plasmodium, the outcomes of DCs activation, and also what is currently known about Plasmodium components that trigger such activation.

Indexed as

Antigen PresentationDendritic CellsHumansImmunologic TestsLife Cycle StagesMalariaPlasmodiumT-Lymphocytes

Identifiers

PMID27110574
PMCPMC4823477
OpenAlexW2307934052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.