ReviewAdvanced biomedical research2016
The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies.
Review in Advanced biomedical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Single-Cell Analysis of L-Myc Expressing Neural Stem Cells and Their Extracellular Vesicles Revealed Distinct Progenitor Populations With Neurogenic Potential.Journal of extracellular biology · 2025Article
- Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury.Scientific reports · 2023Article
- The need for a strategic therapeutic approach: multiple sclerosis in check.Therapeutic advances in chronic disease · 2022Review
- Therapeutic Effects of Photobiomodulation Therapy on Multiple Sclerosis by Regulating the Inflammatory Process and Controlling Immune Cell Activity: A Novel Promising Treatment Target.Journal of lasers in medical sciences · 2022Review
- Human Umbilical Cord Mesenchymal Stem Cells to Treat Neuromyelitis Optica Spectrum Disorder (hUC-MSC-NMOSD): A Study Protocol for a Prospective, Multicenter, Randomized, Placebo-Controlled Clinical Trial.Frontiers in neurology · 2022Article
- The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study.Journal of lasers in medical sciences · 2021Review
- Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis.Stem cell investigation · 2019Review
- A comprehensive review on the treatment approaches of multiple sclerosis: currently and in the future.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Emerging Cellular and Molecular Strategies for Enhancing Central Nervous System (CNS) Remyelination.Brain sciences · 2018Review
- Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia.Stem cells (Dayton, Ohio) · 2018Article
- Transcriptional Profiling of Mesenchymal Stem Cells Identifies Distinct Neuroimmune Pathways Altered by CNS Disease.International journal of stem cells · 2018Article
- Retraction: The Role of Stem Cell Therapy in Multiple Sclerosis: An Overview of the Current Status of the Clinical Studies.Advanced biomedical research · 2018Article
- Long-term stability and computational analysis of migration patterns of L-MYC immortalized neural stem cells in the brain.PloS one · 2018Article
- A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells.Stem cells and cloning : advances and applications · 2018Review
- Yin and Yang of mesenchymal stem cells and aplastic anemia.World journal of stem cells · 2017Review
- Anti-inflammatory effects of hypoxia-preconditioned human periodontal ligament cell secretome in an experimental model of multiple sclerosis: a key role of IL-37.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- A New Chapter for Mesenchymal Stem Cells: Decellularized Extracellular Matrices.Stem cell reviews and reports · 2017Review
- CNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells.Experimental neurology · 2017Article
- Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis.Neural regeneration research · 2017Review
- Methodological aspects of MRI of transplanted superparamagnetic iron oxide-labeled mesenchymal stem cells in live rat brain.PloS one · 2017Article
Corrections and comments
- Retraction · 2018-09-21Plagiarism of/in Article ·
- Retracted
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complexity of multiple sclerosis (MS) and the incompetence of a large number of promised treatments for MS urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. Emerging data propose that hematopoietic, mesenchymal, and neural stem cells have the potential to restore self-tolerance, provide in situ immunomodulation and neuroprotection, as well as promote regeneration. Thus, in this article, we will first provide an overview of the cell sources for proposed mechanisms that contribute to the beneficial effects of stem cell transplantation, the ideal route and/or timing of stem cell-based therapies for each main stem cell group, and finally, an overview of the current status of stem cell research in clinical trial stages in MS by comparable and healthy therapeutic effects of different stem cell therapies for MS patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.