ArticleBrain and behavior2016
Influence of daily social stimulation on behavioral and physiological outcomes in an animal model of PTSD.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Microbial lysate upregulates host oxytocin.Brain, behavior, and immunity · 2017Trial
- Intergenerational influences of paternal combat-related trauma on offspring behavioral and brain function.Neurobiology of stress · 2025Article
- Association between Adverse Childhood Experiences and Multiple Sclerosis in Icelandic Women-A Population-Based Cohort Study.Brain sciences · 2022Article
- Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system.Psychoneuroendocrinology · 2022Review
- Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone.Frontiers in behavioral neuroscience · 2019Review
- Social housing and social isolation: Impact on stress indices and energy balance in male and female Syrian hamsters (Mesocricetus auratus).Physiology & behavior · 2017Article
- Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress.Scientific reports · 2017Article
- Influence of daily social stimulation on behavioral and physiological outcomes in an animal model of PTSD.Brain and behavior · 2016Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionWe have shown in previous work that acute episodes of predator exposure occurring in the context of chronic social instability produced PTSD-like sequelae in rats. Our animal model of PTSD contained two components: (1) acute trauma, immobilization of rats in close proximity to a cat twice in 10 days, and (2) chronic social instability, 31 days of randomized housing of cage cohorts. Here we tested the hypothesis that daily social stimulation would block the development of the PTSD-like sequelae.
methodsBeginning 24 h after the first cat exposure, adult male rats were given our established PTSD model, alone or in conjunction with daily social stimulation, in which all rats within a group interacted in a large apparatus for 2 h each day for the final 30 days of the PTSD regimen. All behavioral, for example, anxiety, memory, startle testing, and physiological assessments, for example, body growth, organ weights, and corticosterone levels, took place following completion of the psychosocial stress period.
resultsDaily social stimulation blocked the expression of a subset of PTSD-like effects, including predator-based cued fear conditioning, enhanced startle response, heightened anxiety on the elevated plus maze and the stress-induced suppression of growth rate. We also found that social stimulation and psychosocial stress produced equivalent outcomes in some measures, including adrenal and heart hypertrophy, thymus atrophy, and a reduction in poststress corticosterone levels.
conclusionsDaily exposure of rats to a highly social environment blocked the development of a subset of trauma-induced sequelae, particularly fear-related outcomes. It is notable that daily social stimulation normalized a subset, but not all, of the PTSD-like effects. We discuss our findings in the context of the literature demonstrating that social stimulation can counteract the adverse effects of traumatic stress on behavioral and physiological measures, as well as to produce its own stress-like outcomes.
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