Evidence map›Paper›PMID 27110425›Full record

ReviewCardiology research and practice2016

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling.

Daniel R Bayzigitov, Sergey P Medvedev, Elena V Dementyeva, Sevda A Bayramova, Evgeny A Pokushalov, Alexander M Karaskov, Suren M Zakian

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiology research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Taking Systems Medicine to Heart.Circulation research · 2018
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Daniel R BayzigitovFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Sergey P MedvedevFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
Elena V DementyevaFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Sevda A BayramovaState Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Evgeny A PokushalovState Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Alexander M KaraskovState Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Suren M ZakianFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
State Research Center of the Russian Federation · RUInstitute of Cytology and Genetics · RUInstitute of Chemical Biology and Fundamental Medicine · RUSiberian Branch of the Russian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

Identifiers

PMID27110425
PMCPMC4826691
OpenAlexW2330436460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.