Evidence map›Paper›PMID 27110344›Full record

ArticleMethods in ecology and evolution2016

The effect of genetic structure on molecular dating and tests for temporal signal.

Gemma G R Murray, Fang Wang, Ewan M Harrison, Gavin K Paterson, Alison E Mather, Simon R Harris, Mark A Holmes, Andrew Rambaut, John J Welch

Abstract read
In one paragraph

Article in Methods in ecology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs.Proceedings of the National Academy of Sciences of the United States of America · 2023
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gemma G R MurrayDepartment of Genetics University of Cambridge Downing Street Cambridge CB2 3EH UK.
Fang WangDepartment of Genetics University of Cambridge Downing Street Cambridge CB2 3EH UK.
Ewan M HarrisonDepartment of Veterinary Medicine University of Cambridge Madingley Road Cambridge CB3 0ES UK.
Gavin K PatersonDepartment of Veterinary Medicine University of Cambridge Madingley Road Cambridge CB3 0ESUK; School of Biological, Biomedical and Environmental Sciences University of Hull Cottingham Road Hull HU6 7RX UK.
Alison E MatherDepartment of Veterinary Medicine University of Cambridge Madingley Road Cambridge CB3 0ESUK; Wellcome Trust Sanger Institute Hinxton CB10 1SA UK.
Simon R HarrisWellcome Trust Sanger Institute Hinxton CB10 1SA UK.
Mark A HolmesDepartment of Veterinary Medicine University of Cambridge Madingley Road Cambridge CB3 0ES UK.
Andrew RambautInstitute of Evolutionary Biology University of Edinburgh King's Buildings Edinburgh EH9 3FL UK.
John J WelchDepartment of Genetics University of Cambridge Downing Street Cambridge CB2 3EH UK.

Funding

Medical Research Council G1001787Medical Research Council MR/P007201/1Wellcome Trust 098051
6 · The paper itself

Abstract

'Dated-tip' methods of molecular dating use DNA sequences sampled at different times, to estimate the age of their most recent common ancestor. Several tests of 'temporal signal' are available to determine whether data sets are suitable for such analysis. However, it remains unclear whether these tests are reliable.We investigate the performance of several tests of temporal signal, including some recently suggested modifications. We use simulated data (where the true evolutionary history is known), and whole genomes of methicillin-resistant

Indexed as

Bayesian datingdated‐tipspathogen originspermutation testsStaphylococcus aureus

Identifiers

PMID27110344
PMCPMC4832290

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.