ReviewAnesthesiology research and practice2016
Comparison of Ondansetron and Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries: A Meta-Analysis of Randomized Controlled Trials.
Review in Anesthesiology research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effects of Drug Administration on Postoperative Pain in Orthognathic Surgery: A Systematic Review.Clinical and experimental dental research · 2025Pooled it
- Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019.World journal of surgery · 2020Pooled it
- Pooled it
- An Investigation into the Association Between Intravenous Crystalloid Administration and Perioperative Nausea and Vomiting in Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2025Trial
- Prevention of postoperative nausea and vomiting after gynaecological day surgery under remimazolam general anesthesia: a randomized double-blind controlled study.BMC anesthesiology · 2022Trial
- Comparison of Ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after orthognathic surgeries: A triple blind randomized controlled trial.Medicina oral, patologia oral y cirugia bucal · 2018Trial
- [Comparison of post-operative nausea and vomiting with intravenous versus inhalational anesthesia in laparotomic abdominal surgery: a randomized clinical trial].Brazilian journal of anesthesiology (Elsevier)Trial
- Efficacy of Combined Ramosetron and Dexamethasone on Postoperative Recovery in Patients Undergoing General Anesthesia: A Multicenter Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Decoding the Genetic Landscape of Postoperative Nausea and Vomiting in Cancer Surgery: A New Frontier in Personalized Medicine Driven by Genome-Wide Association Studies.Indian journal of surgical oncology · 2025Review
- Robotic Pediatric Urologic Surgery-Clinical Anesthetic Considerations: A Comprehensive Review.Anesthesiology and pain medicine · 2024Review
- Analysis of influencing factors and construction of prediction model for postoperative nausea and vomiting in patients undergoing laparoscopic sleeve gastrectomy: a single-center retrospective cohort study.BMC anesthesiology · 2024Article
- Article
- A diagnostic workup and laparoscopic approach for median arcuate ligament syndrome.ANZ journal of surgery · 2022Article
- Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review.F1000Research · 2020Review
- Postoperative nausea and vomiting in bariatric surgery in comparison to non-bariatric gastric surgery.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2019Article
- Perioperative Care of Elderly Surgical Outpatients.Drugs & aging · 2017Review
- An update on the management of postoperative nausea and vomiting.Journal of anesthesia · 2017Review
- Pediatric anesthesia for minimally invasive surgery in pediatric urology.Translational pediatrics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Postoperative nausea and vomiting (PONV) is a significant complication after laparoscopic surgeries. Ondansetron and dexamethasone are most commonly used drugs for PONV prophylaxis. Comparisons of these two drugs have not been systematically reviewed till date. Methods. PubMed, PubMed Central, and CENTRAL databases were searched with the following words: "dexamethasone," "ondansetron," "laparoscopy," and "PONV" to identify randomized trials that compared ondansetron and dexamethasone for PONV prophylaxis after laparoscopic surgeries. Results. Data of 592 patients from 7 RCTs have been included in this meta-analysis. Incidence of postoperative nausea at 4-6 h is significantly lower when dexamethasone was used instead of ondansetron (p = 0.04; OR 0.49, 95% CI 0.24-0.98, M-H fixed). Incidence of nausea is similar at 24 hours (p = 0.08, OR 0.71, 95% CI 0.48, 1.05; M-H fixed); vomiting is also similar at 4-6 h (p = 0.43, OR 1.27, 95% CI 0.70-2.27; M-H fixed) and also at 24 h (p = 0.46, OR 0.92, 95% CI 0.73, 1.16; M-H fixed). Conclusion. Dexamethasone is superior to ondansetron in preventing postoperative nausea after 4-6 h of laparoscopic surgeries. However, both the drugs are of equal efficacy in preventing postoperative vomiting up to 24 h after surgery. However, results should be interpreted with caution due to clinical heterogeneity in the included studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.