ReviewInternational journal of chronic obstructive pulmonary disease2016
The fissure: interlobar collateral ventilation and implications for endoscopic therapy in emphysema.
Review in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Single Arm Pilot Study of Lung Volume Reduction in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves
Combined Zephyr Valve System With Inter-lobar Fissure Completion for Lung Volume Reduction in Emphysema: A Pilot Randomized Controlled Trial
Inter-lobar Fissure Completion as a Salvage Treatment in Patients With Failed Bronchoscopic Lung Volume Reduction
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2017Pooled it
- Seeing is believing-on the utility of CT in phenotyping chronic obstructive pulmonary disease.The British journal of radiology · 2026Review
- Regional ventilation-perfusion changes after endobronchial valve therapy assessed by single-photon emission computed tomography in adults with severe COPD.Scientific reports · 2026Article
- One-lung ventilation with intentional closure of the nonventilated lumen in a patient with giant pulmonary bullae undergoing laparoscopic anterior resection: a case report.AME case reports · 2026Article
- Bronchoscopic endobronchial valves.Breathe (Sheffield, England) · 2026Review
- Predictive value of quantitative CT-derived emphysema heterogeneity for outcomes following bronchoscopic lung volume reduction.American journal of translational research · 2026Article
- Article
- Morphological variations of fissures, lobes, and hilar pattern of the lung in a select South African sample.Surgical and radiologic anatomy : SRA · 2024Observational
- Interventional pulmonology for chronic inflammatory airway diseases.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Quantifying lung fissure integrity using a three-dimensional patch-based convolutional neural network on CT images for emphysema treatment planning.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Role of lung lobar sliding on parenchymal distortion during breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Attention U-net for automated pulmonary fissure integrity analysis in lung computed tomography images.Scientific reports · 2023Article
- Lung Imaging in COPD Part 2: Emerging Concepts.Chest · 2023Review
- Response to endobronchial valve treatment: it's all about the target lobe.ERJ open research · 2023Article
- Bronchoscopic Management of COPD and Advances in Therapy.Life (Basel, Switzerland) · 2023Review
- Variations in Pulmonary Fissure: A Source of Collateral Ventilation and Its Clinical Significance.Cureus · 2022Article
- Use of bronchoscopic steam thermal ablation (BTVA) in a clinically compromised patient.Journal of cardiothoracic surgery · 2022Article
- Accuracy of multidetector computed tomography with maximum intensity projection technique in the assessment of fissure integrity.Journal of thoracic disease · 2022Article
- When Treatment of Pulmonary Emphysema with Endobronchial Valves Did Not Work: Evaluation of Quantitative CT Analysis and Pulmonary Function Tests Before and After Valve Explantation.International journal of chronic obstructive pulmonary disease · 2022Article
- Determinants of Lung Fissure Completeness.American journal of respiratory and critical care medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with severe emphysema, bronchoscopic lung volume reduction using one-way valves is a promising therapeutic option to improve lung function and quality of life. The goal of this treatment is to achieve a complete lobar atelectasis. In a significant proportion of patients, this atelectasis cannot be achieved due to interlobar collateral ventilation. This collateral ventilation is generated through incomplete lobar fissures. Therefore, only patients with complete fissures and no collateral ventilation can be selected for endobronchial therapy with one-way valves. Incomplete fissures are very common and exhibit a great variation in anatomy. The reported prevalence is 17%-85% for the right major fissure, 19%-74% for the left major fissure, and 20%-90% for the minor fissure. There are several methods of measuring or predicting the presence of collateral ventilation, with computed tomography (CT)-fissure analysis and the Chartis measurement being the most important. CT-fissure analysis is an indirect method to measure the completeness of fissures as a surrogate for collateral ventilation. The Chartis system is an endobronchial method to directly measure the presence of collateral ventilation. Both methods have unique value, and the combination of both can accurately predict the treatment response to the bronchoscopic placement of endobronchial valves. This review provides an in-depth view of lung fissure and collateral ventilation to help understand its importance in selecting the appropriate patients for new emphysema treatments and thus avoid useless treatment in unsuitable patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.