ArticleNature communications2016
Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 1,211 citations in OpenAlex.
- FaCPK19-FaTT1 axis decodes heat-induced CaThe New phytologist · 2026Article
- SnRK2.6-mediated phosphorylation stabilizes proteasome regulator 1 (PTRE1) to enhance 26S proteasome activity and coordinate ABA signaling in Arabidopsis.Plant communications · 2026Article
- Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality.Nature communications · 2026Article
- PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy.Frontiers in immunology · 2025Review
- Selective recognition of PTRE1 transcripts mediated by protein-protein interaction between the mPlant communications · 2024Article
- Protein degradation in auxin response.The Plant cell · 2024Review
- High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease.The EMBO journal · 2023Article
- Transcriptome analysis ofChinese herbal medicines · 2023Article
- Transcriptomic Analysis of Hormone Signal Transduction, Carbohydrate Metabolism, Heat Shock Proteins, and SCF Complexes before and after Fertilization of Korean Pine Ovules.International journal of molecular sciences · 2023Article
- RNA-binding protein MAC5A interacts with the 26S proteasome to regulate DNA damage response in Arabidopsis.Plant physiology · 2023Article
- Molecular Mechanisms of Diverse Auxin Responses during Plant Growth and Development.International journal of molecular sciences · 2022Review
- Identification of potential pathways associated with indole-3-butyric acid in citrus bud germination via transcriptomic analysis.Functional & integrative genomics · 2021Article
- mRNA surveillance complex PELOTA-HBS1 regulates phosphoinositide-dependent protein kinase1 and plant growth.Plant physiology · 2021Article
- The CEP5 Peptide Promotes Abiotic Stress Tolerance, As Revealed by Quantitative Proteomics, and Attenuates the AUX/IAA Equilibrium inMolecular & cellular proteomics : MCP · 2020Article
- Genetic and signalling pathways of dry fruit size: targets for genome editing-based crop improvement.Plant biotechnology journal · 2020Review
- The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Proteomic analysis of affinity-purified 26S proteasomes identifies a suite of assembly chaperones inThe Journal of biological chemistry · 2019Article
- The proteasome regulator PTRE1 contributes to the turnover of SNC1 immune receptor.Molecular plant pathology · 2019Article
- PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development.Developmental cell · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant hormone auxin is perceived by the nuclear F-box protein TIR1 receptor family and regulates gene expression through degradation of Aux/IAA transcriptional repressors. Several studies have revealed the importance of the proteasome in auxin signalling, but details on how the proteolytic machinery is regulated and how this relates to degradation of Aux/IAA proteins remains unclear. Here we show that an Arabidopsis homologue of the proteasome inhibitor PI31, which we name PROTEASOME REGULATOR1 (PTRE1), is a positive regulator of the 26S proteasome. Loss-of-function ptre1 mutants are insensitive to auxin-mediated suppression of proteasome activity, show diminished auxin-induced degradation of Aux/IAA proteins and display auxin-related phenotypes. We found that auxin alters the subcellular localization of PTRE1, suggesting this may be part of the mechanism by which it reduces proteasome activity. Based on these results, we propose that auxin regulates proteasome activity via PTRE1 to fine-tune the homoeostasis of Aux/IAA repressor proteins thus modifying auxin activity.
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