Evidence map›Paper›PMID 27109707›Full record

ArticleJournal of molecular modeling2016

Non-covalent carriage of anticancer agents by humanized antibody trastuzumab.

Arpita Yadav, Sweta Sharma, Veejendra Kumar Yadav

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arpita YadavDepartment of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahuji Maharaj University, Kanpur, 208024, India. arpitayadav@yahoo.co.in.
Sweta SharmaDepartment of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahuji Maharaj University, Kanpur, 208024, India.
Veejendra Kumar YadavDepartment of Chemistry, Indian Institute of Technology, Kanpur, 208016, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article explores the internalization and non-covalent carriage of small molecule anticancer agents like vinca alkaloids by humanized monoclonal antibody trastuzumab. Such carriage is marked by significant reduction in side effects and increased therapeutic value of these anticancer agents. This study is coherent with few clinical observations of enhanced efficiency of these anticancer agents when co-administered with therapeutic antibodies. This study will also serve as the foundation for screening a database of anticancer agents for possible compounds that may be co-delivered alongwith the antibody. Based on this study vincristine conformation inside antibody and its charge environment may be used as descriptors for screening purposes.

Indexed as

Antineoplastic AgentsBinding SitesDrug CarriersHumansHydrogen BondingImmunoglobulin Fab FragmentsMolecular Docking SimulationMutationStatic ElectricityThermodynamicsTrastuzumabVinblastineVincristineVinorelbineAntineoplastic AgentsDrug CarriersImmunoglobulin Fab FragmentsTrastuzumabVinblastineVincristineVinorelbineBinding energyMMGBSAMolecular dockingMolecular dynamicsMonoclonal antibodyNon-covalent carriageSimulationSolvation free energyTrastuzumabVinca alkaloid

Identifiers

PMID27109707

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.