Evidence map›Paper›PMID 27109642›Full record

ReviewTranslational stroke research2017

Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke.

Jessica M Cassidy, Steven C Cramer

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational stroke research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 139 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 7 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06110169 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Transcranial Direct Current Stimulation (tDCS) for Neurological Disability Among Subacute Stroke Survivors to Improve Multiple Domains in Quality of Life (QoL): Randomized Controlled Trial Protocol

TypeinterventionalSponsorKarthick BalasubramanianRan2023 to 2024Enrolled64ConditionsStroke, Stroke, IschemicArmsAnodal Transcranial Direct Current Stimulation (Anodal tDCS), Sham Transcranial Direct Current Stimulation (tDCS)
NCT06999876 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia: A Double-blind, Sham-controlled, Randomized Controlled Study

TypeinterventionalSponsorNational University Health System, SingaporeRan2025 to 2026Enrolled90ConditionsStroke Patients With Hemiplegia or Hemiparesis in the Subacute StageArmsThe AscenZ-VIII Stimulator (Investigational Medical Device)
3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 7 syntheses or guidelines pooled it, 289 citations in OpenAlex.

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  5. Combined noninvasive brain stimulation virtual reality for upper limb rehabilitation poststroke: A systematic review of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jessica M CassidyDepartment of Neurology, University of California, Irvine Medical Center, 200 S. Manchester Ave, Suite 206, Orange, CA, 92868-4280, USA.
Steven C CramerDepartment of Neurology, University of California, Irvine Medical Center, 200 S. Manchester Ave, Suite 206, Orange, CA, 92868-4280, USA. scramer@uci.edu.
University of California, Irvine Medical Center · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
U.C. Irvine Multidisciplinary Exercise Science Training ProgramT32AR047752 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, COOPER, DAN M · 2003 to 2018
$2.5M
Brain plasticity and rehabilitation after strokeK24HD074722 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C. · 2013 to 2017
$588k
NCATS NIH HHS UL1 TR001414NIAMS NIH HHS T32 AR047752NICHD NIH HHS K24 HD074722
6 · The paper itself

Abstract

With increasing rates of survival throughout the past several years, stroke remains one of the leading causes of adult disability. Following the onset of stroke, spontaneous mechanisms of recovery at the cellular, molecular, and systems levels ensue. The degree of spontaneous recovery is generally incomplete and variable among individuals. Typically, the best recovery outcomes entail the restitution of function in injured but surviving neural matter. An assortment of restorative therapies exists or is under development with the goal of potentiating restitution of function in damaged areas or in nearby ipsilesional regions by fostering neuroplastic changes, which often rely on mechanisms similar to those observed during spontaneous recovery. Advancements in stroke rehabilitation depend on the elucidation of both spontaneous and therapeutic-driven mechanisms of recovery. Further, the implementation of neural biomarkers in research and clinical settings will enable a multimodal approach to probing brain state and predicting the extent of post-stroke functional recovery. This review will discuss spontaneous and therapeutic-induced mechanisms driving post-stroke functional recovery while underscoring several potential restorative therapies and biomarkers.

Indexed as

Neuronal PlasticityRecovery of FunctionAnimalsBiomarkersBrainHumansNeural PathwaysStrokeTreatment OutcomeBiomarkersBiomarkerNeuroimagingPlasticityRehabilitationRepairStroke

Identifiers

PMID27109642
PMCPMC5079852
OpenAlexW2343101712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.