ArticleScientific reports2016
A novel lineage restricted, pericyte-like cell line isolated from human embryonic stem cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pericytes in tissue fibrosis.American journal of physiology. Cell physiology · 2025Review
- Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke.bioRxiv : the preprint server for biology · 2025Article
- Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells.Biomedicines · 2023Article
- Review
- Bioprinted microvasculature: progressing from structure to function.Biofabrication · 2022Review
- Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier.Theranostics · 2021Review
- Neurovascular Unit: A critical role in ischemic stroke.CNS neuroscience & therapeutics · 2021Review
- Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells.Tissue engineering. Part B, Reviews · 2020Review
- Evaluation of the biofilm formation of Staphylococcus aureus and Pseudomonas aeruginosa on human umbilical cord CD146+ stem cells and stem cell-based decellularized matrix.Cell and tissue banking · 2020Article
- Transcriptome and proteome profiles of human umbilical cord vein CD146+ stem cells.Molecular biology reports · 2020Article
- Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions.Stem cell reports · 2019Article
- Establishment and characterization of an embryonic pericyte cell line.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pericytes (PCs) are endothelium-associated cells that play an important role in normal vascular function and maintenance. We developed a method comparable to GMP quality protocols for deriving self-renewing perivascular progenitors from the human embryonic stem cell (hESC), line ESI-017. We identified a highly scalable, perivascular progenitor cell line that we termed PC-A, which expressed surface markers common to mesenchymal stromal cells. PC-A cells were not osteogenic or adipogenic under standard differentiation conditions and showed minimal angiogenic support function in vitro. PC-A cells were capable of further differentiation to perivascular progenitors with limited differentiation capacity, having osteogenic potential (PC-O) or angiogenic support function (PC-M), while lacking adipogenic potential. Importantly, PC-M cells expressed surface markers associated with pericytes. Moreover, PC-M cells had pericyte-like functionality being capable of co-localizing with human umbilical vein endothelial cells (HUVECs) and enhancing tube stability up to 6 days in vitro. We have thus identified a self-renewing perivascular progenitor cell line that lacks osteogenic, adipogenic and angiogenic potential but is capable of differentiation toward progenitor cell lines with either osteogenic potential or pericyte-like angiogenic function. The hESC-derived perivascular progenitors described here have potential applications in vascular research, drug development and cell therapy.
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