ArticleOral diseases2016
Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes.
Article in Oral diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Non-Surgical Periodontal Treatment Outcomes in Patients with HIV Under Antiretroviral Therapy: A Systematic Review.Journal of clinical medicine · 2026Review
- Lys-specific gingipain (Kgp) ofmBio · 2025Article
- Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.World journal of virology · 2024Review
- Dentists and dental hygienists' comprehension of HIV infection associated periodontal implications and management.Frontiers in public health · 2024Article
- Variability of salivary analytes under daily conditions and their implications for periodontitis biomarkers.Frontiers in dental medicine · 2024Article
- Factors Associated with Periodontitis in Patients with and without HIV.International journal of dentistry · 2023Article
- Relevant mechanisms of MAIT cells involved in the pathogenesis of periodontitis.Frontiers in cellular and infection microbiology · 2023Review
- Periodontal Treatment Reduces Circulating Pro-Inflammatory Cytokine and Chemokine Levels in African American HIV+ Individuals with Virological Suppression.Journal of dental applications · 2022Article
- Unpacking determinants and consequences of food insecurity for insulin resistance among people living with HIV: Conceptual framework and protocol for the NOURISH-OK study.Frontiers in clinical diabetes and healthcare · 2022Article
- Study of Treatment and Reproductive Outcomes Among Reproductive-Age Women With HIV Infection in the Southern United States: Protocol for a Longitudinal Cohort Study.JMIR research protocols · 2021Article
- Women's HIV disclosure to the dentist: Does frequent contact matter?Journal of public health dentistry · 2021Article
- Periodontal Inflammation and Systemic Diseases: An Overview.Frontiers in physiology · 2021Review
- Article
- Current trends and new developments in HIV research and periodontal diseases.Periodontology 2000 · 2020Review
- Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status.AIDS (London, England) · 2018Article
- In Defense of Flossing: Part II-Can We Agree It's Premature to Claim Flossing Is Ineffective to Help Prevent Periodontal Diseases?The journal of evidence-based dental practice · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to determine active periodontal disease status in HIV and to determine the impact of periodontal disease resolution on HIV status.
methodsIn this longitudinal cohort study, 73 HIV-positive subjects received comprehensive dental care. AAP, CDC/AAP, and BGI case definitions determined periodontal classification. Likelihood and frequency of moderate/severe periodontal disease were assessed based on demographic variables. The influence of periodontal intervention was assessed at baseline, 12, and 24 months. IL-6 was measured in a subset of subjects.
resultsOf the periodontal classifications, BGI demonstrated the highest percentage category improvement with the intervention (>50%). Moderate/severe periodontitis was positively associated with HIV regardless of race, smoking status, gender, income level, and age, and was associated with increased IL-6. At baseline, the majority of subjects had severe periodontal disease regardless of ART status. Subjects with suppressed viral load at baseline demonstrated a significant improvement in BGI classification (P = 0.026), increased CD4 counts (P = 0.027), and decreased IL-6 levels (P = 0.03).
conclusionsPeriodontal inflammation was prevalent regardless of ART status. In virologically suppressed subjects, the intervention decreased periodontitis with a concomitant IL-6 decrease and CD4 increase. These findings suggest a relationship between periodontal inflammation, oral microbial translocation, and HIV status.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.