ReviewExperimental neurology2016
Neuroimaging genetic approaches to Posttraumatic Stress Disorder.
Review in Experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Psycho-Somatic Evolution of Patients with Multiple Traumatic Injuries.Clinics and practice · 2024Article
- Treatment of dissociative identity disorder: leveraging neurobiology to optimize success.Expert review of neurotherapeutics · 2024Review
- An explorative study on consequences of abuse on psychological wellbeing and cognitive outcomes in victims of gender-based violence.Frontiers in psychology · 2024Article
- Interventional Mental Health: A Transdisciplinary Approach to Novel Psychiatric Care Delivery.Cureus · 2023Review
- A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder.Focus (American Psychiatric Publishing) · 2023Review
- Decision-Making and Abuse, What Relationship in Victims of Violence?International journal of environmental research and public health · 2023Review
- Article
- Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure.Stress (Amsterdam, Netherlands) · 2019Review
- Posttraumatic stress disorder: from diagnosis to prevention.Military Medical Research · 2018Review
- Amyloid pathology fingerprint differentiates post-traumatic stress disorder and traumatic brain injury.NeuroImage. Clinical · 2018Article
- Past-year nonmedical use of prescription drugs among women on probation and parole: A cross-sectional study.Substance abuse · 2018Article
- Genetic approaches for the study of PTSD: Advances and challenges.Neuroscience letters · 2017Review
- From Engrams to Pathologies of the Brain.Frontiers in neural circuits · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neuroimaging genetic studies that associate genetic and epigenetic variation with neural activity or structure provide an opportunity to link genes to psychiatric disorders, often before psychopathology is discernable in behavior. Here we review neuroimaging genetics studies with participants who have Posttraumatic Stress Disorder (PTSD). Results show that genes related to the physiological stress response (e.g., glucocorticoid receptor and activity, neuroendocrine release), learning and memory (e.g., plasticity), mood, and pain perception are tied to neural intermediate phenotypes associated with PTSD. These genes are associated with and sometimes predict neural structure and function in areas involved in attention, executive function, memory, decision-making, emotion regulation, salience of potential threats, and pain perception. Evidence suggests these risk polymorphisms and neural intermediate phenotypes are vulnerabilities toward developing PTSD in the aftermath of trauma, or vulnerabilities toward particular symptoms once PTSD has developed. Work distinguishing between the re-experiencing and dissociative sub-types of PTSD, and examining other PTSD symptom clusters in addition to the re-experiencing and hyperarousal symptoms, will further clarify neurobiological mechanisms and inconsistent findings. Furthermore, an exciting possibility is that genetic associations with PTSD may eventually be understood through differential intermediate phenotypes of neural circuit structure and function, possibly underlying the different symptom clusters seen within PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.