Evidence map›Paper›PMID 27109104›Full record

ArticleOncogene2016

Breast cancer antiestrogen resistance 3-p130

A M Cross, A L Wilson, M S Guerrero, K S Thomas, A I Bachir, K E Kubow, A R Horwitz, A H Bouton

Abstract read
In one paragraph

Article in Oncogene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Cancers · 2026
    Article
  2. Article
  3. Review
  4. A cellular epithelioid hemangioma of the liver harboring a novel FOS::BCAR3 fusion gene.Virchows Archiv : an international journal of pathology · 2025
    Article
  5. World journal of gastrointestinal oncology · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

A M CrossDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
A L WilsonDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
M S GuerreroFujifilm Diosynth Biotechnologies, USA, Inc., Cary, NC, USA.
K S ThomasDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
A I BachirDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
K E KubowDepartment of Biology, James Madison University, Harrisonburg, VA, USA.
A R HorwitzDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
A H BoutonDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
University of Virginia · USFujifilm (United States) · USJames Madison University · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
DETERMINANTS OF MYOGENIC MEMBRANE PHENOMENAR01GM023244 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HORWITZ, ALAN F. "RICK" · 1985 to 2014
$6.7M
Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen ResponseR01CA096846 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BOUTON, AMY H. · 2003 to 2013
$2.4M
DETERMINANTS OF MYOGENIC MEMBRANE PHENOMENAR37GM023244 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HORWITZ, ALAN F · 1992 to 2002
$1.1M
Mechanisms of Cell Signaling in BCAR3-mediated Anti-Estrogen ResistanceF31CA130168 · NCI · UNIVERSITY OF VIRGINIA · PI GUERRERO, MICHAEL S · 2007 to 2010
$116k
BCAR3 and its Role in Breast Tumor Progression, Invasion, and MetastasisF31CA165703 · NCI · UNIVERSITY OF VIRGINIA · PI WILSON, ASHLEY LAUREN · 2012 to 2014
$88k
NCI NIH HHS F31 CA130168NCI NIH HHS F31 CA165703NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA096846NCI NIH HHS T32 CA009109NIGMS NIH HHS R01 GM023244NIGMS NIH HHS R37 GM023244
6 · The paper itself

Abstract

Adhesion turnover is critical for cell motility and invasion. We previously demonstrated that the adaptor molecule breast cancer antiestrogen resistance 3 (BCAR3) promotes adhesion disassembly and breast tumor cell invasion. One of two established binding partners of BCAR3 is the adaptor molecule, p130

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBreast NeoplasmsCarrier ProteinsCell AdhesionCell Line, TumorCell MovementCrk-Associated Substrate ProteinFemaleFibroblastsGene ExpressionGuanine Nucleotide Exchange FactorsHumansMiceModels, BiologicalMultiprotein ComplexesAdaptor Proteins, Signal TransducingBCAR3 protein, humanCarrier ProteinsCrk-Associated Substrate ProteinGuanine Nucleotide Exchange FactorsMultiprotein Complexes

Identifiers

PMID27109104
PMCPMC5079856
OpenAlexW2344322787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.