ArticleVirus genes2016
Genome sequence and origin analyses of the recombinant novel IBV virulent isolate SAIBK2.
Article in Virus genes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Emergence of novel QX-type IBV in China: molecular insights into unique S protein cleavage sites, antigenic drift, and enhanced pathogenicity (2025).BMC veterinary research · 2025Article
- Isolation of a more aggressive GVI-1 genotype strain HX of the avian infectious bronchitis virus.Poultry science · 2024Article
- Complete Genome Sequences of Infectious Bronchitis Virus Genotype JP-II (GI-7) and JP-III (GI-19) Strains Isolated in Japan.Microbiology resource announcements · 2023Article
- Complete Genome Sequences of Two JP-I (GI-18) Genotype Infectious Bronchitis Virus Strains Isolated from Chickens with Nephritis in Japan.Microbiology resource announcements · 2022Article
- Complete Genome Sequence of Infectious Bronchitis Virus Strain JP/KH/64, Isolated in Japan.Microbiology resource announcements · 2021Article
- Article
- A novel low virulent respiratory infectious bronchitis virus originating from the recombination of QX, TW and 4/91 genotype strains in China.Veterinary microbiology · 2020Article
- Article
- Article
- Comparative features of infections of two Massachusetts (Mass) infectious bronchitis virus (IBV) variants isolated from Western Canadian layer flocks.BMC veterinary research · 2018Article
- Molecular characteristic and pathogenicity analysis of a virulent recombinant avain infectious bronchitis virus isolated in China.Poultry science · 2018Article
- miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18.Microbial pathogenesis · 2018Article
- Comparative transcriptome analysis reveals induction of apoptosis in chicken kidney cells associated with the virulence of nephropathogenic infectious bronchitis virus.Microbial pathogenesis · 2017Article
- First characterization of a Middle-East GI-23 lineage (Var2-like) of infectious bronchitis virus in Europe.Virus research · 2017Article
- Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation.International journal of molecular sciences · 2017Review
- Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 Cells.Viruses · 2017Article
- Identification of a novel recombinant virulent avian infectious bronchitis virus.Veterinary microbiology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination between infectious bronchitis viruses (IBVs), together with point mutations, insertions, and deletions, is thought to be responsible for the emergence of new IBV variants. SAIBK2 is a nephropathogenic strain isolated from layer flocks vaccinated with live attenuated H120 vaccine in Sichuan province, China in 2011. SAIBK2 causes severe kidney lesions and results in 50 % mortality in 30-day-old specific-pathogen-free chickens (with a dose of 10(5) EID50/0.1 mL SAIBK2 per chicken). The complete genome of SAIBK2 consists of 27669 nucleotides, excluding the poly-A tail at the 3' end. SAIBK2 has the highest identity to YX10 in terms of complete genome. Phylogenetic analysis of complete sequence showed that SAIBK2 belongs to the most dominant genotype in China. Comparison and recombination analyses with other IBV strains revealed that SAIBK2 may originate from recombination events among a YX10-, a YN-, and a Mass-like strain. Furthermore, whole gene 5 and parts of nsp 3, nsp 4, nsp 16, and N genes are involved in the recombination events, and the uptake of these regions from YN and Mass strains by SAIBK2 may increase its replication efficiency and be responsible for its increased virulence in specific-pathogen-free chickens.
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