Evidence map›Paper›PMID 27108705›Full record

ReviewNature reviews. Microbiology2016

Chlamydia cell biology and pathogenesis.

Cherilyn Elwell, Kathleen Mirrashidi, Joanne Engel

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 412 papers.

0numbers the graph read from it
0cells of the map it votes in
412citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

412 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Live Imaging of Ions in Cells Infected with Chlamydia trachomatis.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  5. High-Resolution Detection of Chlamydia Proteins by Expansion Microscopy.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Plasmid-encoded Pgp3 protein enhances the infectivity ofZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  11. Microbiology spectrum · 2026
    Article
  12. Article
  13. Article
  14. High Burden ofMicroorganisms · 2026
    Article
  15. Review
  16. Article
  17. CD8iScience · 2026
    Article
  18. Article
  19. Article
  20. Article

352 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cherilyn ElwellDepartments of Medicine, Microbiology and Immunology, University of California, San Francisco, California 94143, USA.
Kathleen MirrashidiDepartments of Medicine, Microbiology and Immunology, University of California, San Francisco, California 94143, USA.
Joanne EngelDepartments of Medicine, Microbiology and Immunology, University of California, San Francisco, California 94143, USA.

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Novel approaches to identify host genes required for Chlamydia pathogenesisR01AI073770 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N. · 2007 to 2016
$3.8M
Decoding the Chlamydia inclusion membrane protein-host protein interactomeR01AI122747 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N., KAAKE, ROBYN MIDORI · 2016 to 2020
$3.1M
High throughput proteomics to dissect Chlamydia-host cell interactionsR21AI105561 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N. · 2013 to 2014
$419k
NIAID NIH HHS R01 AI073770NIAID NIH HHS R01 AI122747NIAID NIH HHS R21 AI105561NIAID NIH HHS T32 AI060537
6 · The paper itself

Abstract

Chlamydia spp. are important causes of human disease for which no effective vaccine exists. These obligate intracellular pathogens replicate in a specialized membrane compartment and use a large arsenal of secreted effectors to survive in the hostile intracellular environment of the host. In this Review, we summarize the progress in decoding the interactions between Chlamydia spp. and their hosts that has been made possible by recent technological advances in chlamydial proteomics and genetics. The field is now poised to decipher the molecular mechanisms that underlie the intimate interactions between Chlamydia spp. and their hosts, which will open up many exciting avenues of research for these medically important pathogens.

Indexed as

Host-Pathogen InteractionsBacterial ProteinsChlamydiaChlamydia InfectionsChlamydia trachomatisCytoplasmHumansImmunity, InnateProteomicsType V Secretion SystemsBacterial ProteinsType V Secretion Systems

Identifiers

PMID27108705
PMCPMC4886739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.