ArticleDie Naturwissenschaften2016
Bitter-sensitive gustatory receptor neuron responds to chemically diverse insect repellents in the common malaria mosquito Anopheles quadrimaculatus.
Article in Die Naturwissenschaften, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- Gustation in insects: taste qualities and types of evidence used to show taste function of specific body parts.Journal of insect science (Online) · 2023Article
- Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis ofInternational journal of molecular sciences · 2022Article
- In Search of Synergistic Insect Repellents: Modeling of Muscarinic GPCR Interactions with Classical and Bitopic Photoactive Ligands.Molecules (Basel, Switzerland) · 2022Article
- Review
- Article
- The mosquito taste system and disease control.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Membrane Proteins Mediating Reception and Transduction in Chemosensory Neurons in Mosquitoes.Frontiers in physiology · 2018Review
- Notes on the Recent History of Neuroscience in Africa.Frontiers in neuroanatomy · 2017Review
- Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit.PloS one · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Female mosquitoes feed on blood from animal hosts to obtain nutritional resources used for egg production. These contacts facilitate the spread of harmful human diseases. Chemical repellents are used to disrupt mosquito host-seeking and blood-feeding behaviors; however, little is known about the gustatory sensitivity of mosquitoes to known repellents. Here, we recorded electrical responses from gustatory receptor neurons (GRNs) housed within the labellar sensilla of female Anopheles quadrimaculatus to N,N-diethyl-3-methylbenzamide (DEET), picaridin, IR3535, 2-undecanone, p-menthane-3,8-diol, geraniol, trans-2-hexen-1-ol, quinine, and quinidine. A bitter-sensitive GRN responded to all tested repellents and quinine, a known feeding deterrent. Responses of the bitter-sensitive neuron to quinine and an isomer, quinidine, did not differ. Delayed bursts of electrical activity were observed in response to continuous stimulation with synthetic repellents at high concentrations. Electrophysiological recordings from bitter-sensitive GRNs associated with mosquito gustatory sensilla represent a convenient model to evaluate candidate repellents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.