Evidence map›Paper›PMID 27108395›Full record

ArticleStem cell research2016

Identifying gene expression modules that define human cell fates.

I Germanguz, J Listgarten, J Cinkornpumin, A Solomon, X Gaeta, W E Lowry

Open access · goldAbstract read
In one paragraph

Article in Stem cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

I GermanguzMolecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
J ListgartenMicrosoft Research, United States.
J CinkornpuminMolecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
A SolomonMolecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
X GaetaMolecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States.
W E LowryMolecular, Cell and Developmental Biology, UCLA, United States; Eli and Edythe Broad Center for Regenerative Medicine, UCLA, United States; Molecular Biology Institute, UCLA, United States. Electronic address: blowry@ucla.edu.
Broad Center · USMicrosoft (United States) · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Roles of sumoylation and alternative polyadenylation in cellular reprogrammingP01GM099134 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PLATH, KATHRIN · 2011 to 2021
$20.3M
NCI NIH HHS P30 CA016042NIGMS NIH HHS P01 GM099134
6 · The paper itself

Abstract

Using a compendium of cell-state-specific gene expression data, we identified genes that uniquely define cell states, including those thought to represent various developmental stages. Our analysis sheds light on human cell fate through the identification of core genes that are altered over several developmental milestones, and across regional specification. Here we present cell-type specific gene expression data for 17 distinct cell states and demonstrate that these modules of genes can in fact define cell fate. Lastly, we introduce a web-based database to disseminate the results.

Indexed as

AlgorithmsCell DifferentiationCells, CulturedCellular ReprogrammingGene ExpressionGene Regulatory NetworksHumansTranscription FactorsTranscription Factors

Identifiers

PMID27108395
PMCPMC4903895
OpenAlexW2340176586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.