ArticleJournal of applied genetics2016
Expression of genes involved in lipid droplet formation (BSCL2, SNAP23 and COPA) during porcine in vitro adipogenesis.
Article in Journal of applied genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
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- Effects of high-protein concentrates with different rumen undegradable-to-degradable protein ratios on performance and carcass traits in 26-month-slaughtered Hanwoo steers.Animal bioscience · 2025Article
- Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B.Cell discovery · 2023Article
- The Effect ofAnimals : an open access journal from MDPI · 2023Article
- Supplementation with rumen-inert fat in the growing phase altered adipogenic gene expression and the size and number of adipocytes in Hanwoo steers.Journal of animal science · 2023Article
- Lipid droplet dynamics in healthy and pyometra-affected canine endometrium.BMC veterinary research · 2022Article
- Importance of lipids for upper motor neuron health and disease.Seminars in cell & developmental biology · 2021Review
- OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis.iScience · 2020Article
- Whole Genome Sequence Data Provides Novel Insights Into the Genetic Architecture of Meat Quality Traits in Beef.Frontiers in genetics · 2020Article
- Article
- The importance of the nuclear positioning of the PPARG gene for its expression during porcine in vitro adipogenesis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Article
- Nuclear organization during in vitro differentiation of porcine mesenchymal stem cells (MSCs) into adipocytes.Histochemistry and cell biology · 2018Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipogenesis is a complex process of fat cells development driven by the expression of numerous genes. Differentiation of progenitor cells into mature adipocytes is accompanied by changes in cell shape, as a result of lipid accumulation. In the present study, expression of three genes involved in lipid droplet formation (SNAP23, BSCL2 and COPA) was evaluated during porcine adipogenesis. It was found that mRNA levels of BSCL2 and SNAP23, but not COPA, increased during differentiation. Redistribution of SNAP23 protein to different cellular compartments was observed when comparing undifferentiated mesenchymal stem cells and differentiated adipocytes. The BSCL2 protein was found to be highly specific to cells with accumulated lipids, while COPA protein coated the lipid droplets. Obtained results indicated that the studied genes may be considered as candidates for fatness traits in pigs. Moreover, this study has shown that the porcine in vitro adipogenesis system provides a useful tool for the characterisation of novel genes involved in adipose tissue accumulation.
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