Evidence map›Paper›PMID 27108298›Full record

Observational studyEuropean radiology2017

Late recanalisation beyond 24 hours is associated with worse outcome: an observational study.

Shenqiang Yan, Mengjun Xu, Quan Han, Keqi Ye, Yangxiao Lai, Keqin Liu, David S Liebeskind, Min Lou

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shenqiang YanDepartment of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou, China.
Mengjun XuDepartment of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou, China.
Quan HanDepartment of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou, China.
Keqi YeDepartment of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou, China.
Yangxiao LaiDepartment of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou, China.
Keqin LiuDepartment of Neurology, Hangzhou First People's Hospital, Hangzhou, China.
David S LiebeskindUniversity of California-Los Angeles Stroke Center, Los Angeles, CA, USA.
Min LouDepartment of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou, China. loumingxc@vip.sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe evaluated the rate of late recanalisation beyond 24 h after intravenous thrombolysis (IVT) and its relationship with haemorrhagic transformation and outcome.

methodsWe reviewed prospectively collected clinical and imaging data from acute ischaemic stroke patients with distal internal carotid artery or proximal middle cerebral artery occlusion who underwent angiography on admission, 24 h and 1 week after IVT. Patients were trichotomised according to vascular status: timely recanalisation (<24 h), late recanalisation (24 h-7 days), and no recanalisation.

resultsNon-invasive angiography revealed timely recanalisation in 52 (50.0 %) patients, late recanalisation in 25 (24.0 %) patients, and no recanalisation in 27 (26.0 %) patients. Pre-existing atrial fibrillation was associated with the occurrence of late recanalisation (odds ratio 6.674; 95 % CI: 1.197 to 37.209; p = 0.030). In patients without timely recanalisation, shift analysis indicated that late recanalisation led to a worse modified Rankin Scale score (odds ratio 6.787; 95 % CI: 2.094 to 21.978; p = 0.001).

conclusionsAbout half of all patients without recanalisation by 24 h after IVT may develop late recanalisation within 1 week, along with higher mRS scores by 3 months. Pre-existing atrial fibrillation is an independent predictor for late recanalisation. KEY POINTS: • About half of patients may develop late recanalisation within 1 week. • Pre-existing atrial fibrillation was associated with the occurrence of late recanalisation. • Late recanalisation led to a higher mRS score than no recanalisation.

Indexed as

Administration, IntravenousAdultAgedAged, 80 and overBrain IschemiaCerebral AngiographyFemaleFibrinolytic AgentsHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeFibrinolytic AgentsTissue Plasminogen ActivatorAngiographyMiddle cerebral artery occlusionOutcome assessmentStrokeThrombolytic therapy

Identifiers

PMID27108298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.