ArticleEuropean archives of psychiatry and clinical neuroscience2016
Negative symptoms and their association with depressive symptoms in the long-term course of schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Placebo effects of repetitive transcranial magnetic stimulation on negative symptoms and cognition in patients with schizophrenia spectrum disorders: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Effects of Exercise on Positive Symptoms, Negative Symptoms, and Depression in Patients with Schizophrenia: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Correspondence between negative symptoms and potential sources of secondary negative symptoms over time.European archives of psychiatry and clinical neuroscience · 2018Trial
- Negative symptoms and resting state functional connectivity: Leveraging ecological momentary assessment and individual-specific techniques.Schizophrenia research · 2026Article
- Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders - A retrospective analysis.Brain, behavior, & immunity - health · 2026Article
- Association of metabolic syndrome with comorbid major depressive disorder in remitted schizophrenia: a cross-sectional study.BMC psychiatry · 2026Article
- Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia.International journal of molecular sciences · 2025Review
- Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated With Psychopathology Across Independent Cohorts.Biological psychiatry · 2025Article
- Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression.Neuropsychiatric disease and treatment · 2025Article
- Symptoms of depression in middle-aged and older adults with schizophrenia in Guangzhou, China: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS).Brain sciences · 2024Article
- Abnormal hedonic process in patients with stable schizophrenia: Relationships to negative symptoms and social functioning.Schizophrenia research. Cognition · 2024Article
- Efficacy of Horticultural Therapy on Positive, Negative, and Affective Symptoms in Individuals with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2024Review
- Prescription Digital Therapeutics: An Emerging Treatment Option for Negative Symptoms in Schizophrenia.Biological psychiatry · 2024Review
- Pharmacological Treatments of Negative Symptoms in Schizophrenia-An Update.Journal of clinical medicine · 2024Review
- 16S rRNA gene sequencing reveals altered gut microbiota in young adults with schizophrenia and prominent negative symptoms.Brain and behavior · 2024Article
- Effect of 12-week shen-based qigong exercise on the residual symptoms of schizophrenia: Study protocol for a single-centre randomised controlled trial.Contemporary clinical trials communications · 2023Article
- Treatment of Depression with Vortioxetine and Second Generation Antipsychotics During the Period of Remission Formation in Schizophrenia (Interim Data Analysis).Consortium psychiatricum · 2023Article
- Preliminary evidence that fatigue contributes to anhedonia in stable individuals diagnosed with schizophrenia.Frontiers in psychiatry · 2023Article
- Optimal cutoff scores of the Chinese version of 15-item negative symptom assessment that indicate prominent negative symptoms of schizophrenia.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Depressive symptoms abound in schizophrenia and even in subclinical states of the disorder. We studied the frequency of these symptoms and their relationship to negative symptoms from the first psychotic episode on over a long-term course of 134 months on data for 107 patients in our ABC Schizophrenia Study. Prevalence rates of 90 % for presenting at least one negative symptom and of 60 % for presenting at least one depressive symptom in the first psychotic episode illustrate the frequency of these syndromes. After the remission of psychosis the rates fell to 50 % (negative symptoms) and 40 % (depressive symptoms) over a period of 5 years, remaining stable thereafter. After we broke the negative syndrome down into (SANS) subsyndromes, a positive association emerged between anhedonia and depressive symptoms and remained stable over the entire period studied. In contrast, the association between abulia and depression grew increasingly pronounced over the illness course. However, a more detailed look revealed this to be the case in female patients only, whereas male patients showed no such association of these symptom dimensions. We have no explanation at hand for this sex difference yet.
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