ArticleJournal of neuroinflammation2016
Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis.
Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Bioelectrical impedance analysis to assess body water status during fluid infusion in a rat model of extracorporeal membrane oxygenation.Scientific reports · 2025Article
- Review
- The Correlation between the Increased Expression of Aquaporins on the Inner Limiting Membrane and the Occurrence of Diabetic Macular Edema.Oxidative medicine and cellular longevity · 2022Article
- Article
- Role of Aquaporins in Inflammation-a Scientific Curation.Inflammation · 2020Review
- Immunological Insights in Equine Recurrent Uveitis.Frontiers in immunology · 2020Review
- Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration.Journal of clinical medicine · 2019Article
- Article
- Gestational diabetes influences retinal Muller cells in rat's offspring.Iranian journal of basic medical sciences · 2017Article
- Expression and Distribution Pattern of Aquaporin 4, 5 and 11 in Retinas of 15 Different Species.International journal of molecular sciences · 2016Article
- Intake of dietary salt and drinking water: Implications for the development of age-related macular degeneration.Molecular vision · 2016Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMüller glial cells are important regulators of physiological function of retina. In a model disease of retinal inflammation and spontaneous recurrent uveitis in horses (ERU), we could show that retinal Müller glial cells significantly change potassium and water channel protein expression during autoimmune pathogenesis. The most significantly changed channel protein in neuroinflammatory ERU was aquaporin 11 (AQP11). Aquaporins (AQP, 13 members) are important regulators of water and small solute transport through membranes. AQP11 is an unorthodox member of this family and was assigned to a third group of AQPs because of its difference in amino acid sequence (conserved sequence is only 11 %) and especially its largely unknown function.
methodsIn order to gain insight into the distribution, localization, and function of AQP11 in the retina, we first developed a novel monoclonal antibody for AQP11 enabling quantification, localization, and functional studies.
resultsIn the horse retina, AQP11 was exclusively expressed at Müller glial cell membranes. In uveitic condition, AQP11 disappeared from gliotic Müller cells concomitant with glutamine synthase. Since function of AQP11 is still under debate, we assessed the impact of AQP11 channel on cell volume regulation of primary Müller glial cells under different osmotic conditions. We conclude a concomitant role for AQP11 with AQP4 in water efflux from these glial cells, which is disturbed in ERU. This could probably contribute to swelling and subsequent severe complication of retinal edema through impaired intracellular fluid regulation.
conclusionsTherefore, AQP11 is important for physiological Müller glia function and the expression pattern and function of this water channel seems to have distinct functions in central nervous system. The significant reduction in neuroinflammation points to a crucial role in pathogenesis of autoimmune uveitis.
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