Evidence map›Paper›PMID 27107449›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2016

An efficient approach for surveillance of childhood diabetes by type derived from electronic health record data: the SEARCH for Diabetes in Youth Study.

Victor W Zhong, Jihad S Obeid, Jean B Craig, Emily R Pfaff, Joan Thomas, Lindsay M Jaacks, Daniel P Beavers, Timothy S Carey, Jean M Lawrence, Dana Dabelea and 5 more

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Victor W ZhongDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Jihad S ObeidBiomedical Informatics Center, Medical University of South Carolina, Charleston, SC, USA.
Jean B CraigBiomedical Informatics Center, Medical University of South Carolina, Charleston, SC, USA.
Emily R PfaffNorth Carolina TraCS Institute, University of North Carolina, Chapel Hill, NC, USA.
Joan ThomasDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Lindsay M JaacksHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Daniel P BeaversDepartment of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Timothy S CareyCecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC, USA.
Jean M LawrenceDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Richard F HammanDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Deborah A BowlbyDivision of Pediatric Endocrinology, Medical University of South Carolina, Charleston, SC, USA.
Catherine PihokerDepartment of Washington, University of Washington, Seattle, WA, USA.
Sharon H SaydahCenters for Disease Control and Prevention, Division of Diabetes Translation, Atlanta, GA, USA.
Elizabeth J Mayer-DavisDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA ejmayer_davis@unc.edu.

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort StudyUC4DK108173 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2015 to 2016
$14.8M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000154NCCDPHP CDC HHS U18 DP006139NIDDK NIH HHS P30 DK056350NIDDK NIH HHS UC4 DK108173
6 · The paper itself

Abstract

objectiveTo develop an efficient surveillance approach for childhood diabetes by type across 2 large US health care systems, using phenotyping algorithms derived from electronic health record (EHR) data. MATERIALS AND

methodsPresumptive diabetes cases <20 years of age from 2 large independent health care systems were identified as those having ≥1 of the 5 indicators in the past 3.5 years, including elevated HbA1c, elevated blood glucose, diabetes-related billing codes, patient problem list, and outpatient anti-diabetic medications. EHRs of all the presumptive cases were manually reviewed, and true diabetes status and diabetes type were determined. Algorithms for identifying diabetes cases overall and classifying diabetes type were either prespecified or derived from classification and regression tree analysis. Surveillance approach was developed based on the best algorithms identified.

resultsWe developed a stepwise surveillance approach using billing code-based prespecified algorithms and targeted manual EHR review, which efficiently and accurately ascertained and classified diabetes cases by type, in both health care systems. The sensitivity and positive predictive values in both systems were approximately ≥90% for ascertaining diabetes cases overall and classifying cases with type 1 or type 2 diabetes. About 80% of the cases with "other" type were also correctly classified. This stepwise surveillance approach resulted in a >70% reduction in the number of cases requiring manual validation compared to traditional surveillance methods.

conclusionEHR data may be used to establish an efficient approach for large-scale surveillance for childhood diabetes by type, although some manual effort is still needed.

Indexed as

AlgorithmsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Electronic Health RecordsAdolescentChildChild, PreschoolClinical CodingFemaleHumansInfantMalePopulation SurveillanceSensitivity and SpecificityYoung Adultascertainment and classificationautomated algorithmchildhood diabeteselectronic health recordssurveillance

Identifiers

PMID27107449
PMCPMC5070516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.