ArticleEnvironment international
Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers.
Article in Environment international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence.International journal of public health · 2019Pooled it
- Effect of Reducing Ambient Traffic-Related Air Pollution on Blood Pressure: A Randomized Crossover Trial.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Air quality and health implications of exposure to ultrafine particle pollution.Cardiovascular research · 2026Article
- Article
- Concentration-Response Functions Relating Concentration and Duration of Ambient Traffic-Related Air Pollution Exposure to Systolic Blood Pressure.Environmental health perspectives · 2024Article
- Article
- Communities catalyzing change with data to mitigate an invisible menace, traffic-related air pollution.BMC public health · 2024Article
- Review
- Article
- Exposure to ultrafine particles and cognitive decline among older people in the United States.Environmental research · 2023Article
- Design and evaluation of short-term monitoring campaigns for long-term air pollution exposure assessment.Journal of exposure science & environmental epidemiology · 2023Article
- Relationship between traffic-related air pollution and inflammation biomarkers using structural equation modeling.The Science of the total environment · 2023Article
- Article
- A new exposure metric for the cumulative effect of short-term exposure peaks of traffic-related ultrafine particles.Journal of exposure science & environmental epidemiology · 2022Article
- Coagulation patterns and the impacts on traffic-related ultrafine particle dispersion in road tunnels employing dynamic mesh algorithms.Environmental science and pollution research international · 2021Article
- Maternal exposure to OEnvironmental science and pollution research international · 2021Article
- The Acute Effect of Diesel Exhaust Particles and Different Fractions Exposure on Blood Coagulation Function in Mice.International journal of environmental research and public health · 2021Article
- Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020Review
- CBPR Partnerships and Near-Roadway Pollution: A Promising Strategy to Influence the Translation of Research into Practice.Environments (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLong-term exposure to fine particulate matter has been linked to cardiovascular disease and systemic inflammatory responses; however, evidence is limited regarding the effects of long-term exposure to ultrafine particulate matter (UFP, <100nm). We used a cross-sectional study design to examine the association of long-term exposure to near-highway UFP with measures of systemic inflammation and coagulation.
methodsWe analyzed blood samples from 408 individuals aged 40-91years living in three near-highway and three urban background areas in and near Boston, Massachusetts. We conducted mobile monitoring of particle number concentration (PNC) in each area, and used the data to develop and validate highly resolved spatiotemporal (hourly, 20m) PNC regression models. These models were linked with participant time-activity data to determine individual time-activity adjusted (TAA) annual average PNC exposures. Multivariable regression modeling and stratification were used to assess the association between TAA-PNC and single peripheral blood measures of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor-necrosis factor alpha receptor II (TNFRII) and fibrinogen.
resultsAfter adjusting for age, sex, education, body mass index, smoking and race/ethnicity, an interquartile-range (10,000particles/cm(3)) increase in TAA-PNC had a positive non-significant association with a 14.0% (95% CI: -4.6%, 36.2%) positive difference in hsCRP, an 8.9% (95% CI: -0.4%, 10.9%) positive difference in IL-6, and a 5.1% (95% CI: -0.4%, 10.9%) positive difference in TNFRII. Stratification by race/ethnicity revealed that TAA-PNC had larger effect estimates for all three inflammatory markers and was significantly associated with hsCRP and TNFRII in white non-Hispanic, but not East Asian participants. Fibrinogen had a negative non-significant association with TAA-PNC.
conclusionsOur findings suggest an association between annual average near-highway TAA-PNC and subclinical inflammatory markers of CVD risk.
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