ArticlePlant biotechnology journal2016
The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.
Article in Plant biotechnology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 2 of them syntheses that pooled it.
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Who cites it
163 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interplay among ZF-HD and GRF transcription factors during Arabidopsis leaf development.Plant physiology · 2023Pooled it
- Perennials as Future Grain Crops: Opportunities and Challenges.Frontiers in plant science · 2022Pooled it
- Common genetic control for grain filling duration and kernel weight in grain sorghum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The multifaceted regulatory network of microRNA396: Orchestrating plant plasticity through coordinating development and various stresses.Journal of integrative plant biology · 2026Review
- Article
- SlGRF1 mediates gibberellin signaling to control cut-budding in tomato.Journal of integrative plant biology · 2026Article
- The miR396f-GRF7 Module Confers Thermotolerance in Rice.Rice (New York, N.Y.) · 2026Article
- Determinants of Rice Grain Quality: Synergistic Roles of Genetics, Environment, and Agronomic Practices.International journal of molecular sciences · 2026Review
- Physiological and Transcriptomic Analysis of Bread Wheat MicroRNAs in Response to Zinc Availability.Biomolecules · 2026Article
- Article
- The LARGE1 controls grain size by repressing the interaction between PGL2 and APG in rice.The Plant journal : for cell and molecular biology · 2026Article
- From binding to networks: methods for identifying transcription factor targets in plant systems.Frontiers in plant science · 2026Review
- Genome wide association mapping and haplotype analysis identify genetic loci and candidate genes associated with yield related traits in rice (Frontiers in plant science · 2026Article
- CRISPR-Cas technologies for precision genome editing in plants: advances, applications, and future perspectives.Frontiers in plant science · 2026Review
- Small but big player: the important role of microRNAs in rice.Frontiers in plant science · 2026Review
- Genome-wide identification and characterization of the growth-regulating factor gene family in oat (Frontiers in plant science · 2026Article
- OsnTNB.11 Encodes a CC-NBS-LRR Type Resistance Protein that Positively Regulates Resistance to Rice Kernel Smut by Modulating the Ethylene Signalling.Rice (New York, N.Y.) · 2025Article
- Comparative Transcriptomics Analysis Reveals Genes Associated with a Dehiscent-Corolla Mutant in Sesame (International journal of molecular sciences · 2025Article
- Identification and characterization of the miR396f-GRF10 module in phase transition of Lilium.Planta · 2025Article
- Insight into the Functional Role of SiMPK6 in Stress Response and Photosynthetic Efficiency inPlants (Basel, Switzerland) · 2025Article
103 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grain weight is the most important component of rice yield and is mainly determined by grain size, which is generally controlled by quantitative trait loci (QTLs). Although numerous QTLs that regulate grain weight have been identified, the genetic network that controls grain size remains unclear. Herein, we report the cloning and functional analysis of a dominant QTL, grain length and width 2 (GLW2), which positively regulates grain weight by simultaneously increasing grain length and width. The GLW2 locus encodes OsGRF4 (growth-regulating factor 4) and is regulated by the microRNA miR396c in vivo. The mutation in OsGRF4 perturbs the OsmiR396 target regulation of OsGRF4, generating a larger grain size and enhanced grain yield. We also demonstrate that OsGIF1 (GRF-interacting factors 1) directly interacts with OsGRF4, and increasing its expression improves grain size. Our results suggest that the miR396c-OsGRF4-OsGIF1 regulatory module plays an important role in grain size determination and holds implications for rice yield improvement.
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