ArticleApplied and environmental microbiology2016
Genotypic and Phenotypic Markers of Livestock-Associated Methicillin-Resistant Staphylococcus aureus CC9 in Humans.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Transmission routes of antibiotic resistant bacteria: a systematic review.BMC infectious diseases · 2022Pooled it
- Inferring Staphylococcus aureus host species and cross-species transmission from a genome-based model.BMC genomics · 2025Article
- Molecular Characterization of ChimericMicroorganisms · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Heterogeneity and transmission of food safety-related enterotoxigenicMicrobiology spectrum · 2023Article
- The Epidemiology of Animal-Associated Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- Methicillin-resistantEmerging microbes & infections · 2022Article
- Survey of Staphylococcus aureus carriage by free-living red deer (Cervus elaphus): Evidence of human and domestic animal lineages.Transboundary and emerging diseases · 2022Article
- Tracking Infection and Genetic Divergence of Methicillin-ResistantFrontiers in veterinary science · 2022Article
- First Report of Antimicrobial Susceptibility and Virulence Gene Characterization Associated withAnimals : an open access journal from MDPI · 2021Article
- Review
- Genomic Insights into Methicillin-Resistant Staphylococcus aureusApplied and environmental microbiology · 2021Article
- Livestock-Associated and Non-Livestock-AssociatedInfection and drug resistance · 2021Article
- HumanMicroorganisms · 2020Review
- Acquisition Risk Factors of the SCCAntibiotics (Basel, Switzerland) · 2020Article
- High concentration of coagulase-negative staphylococci carriage among bioaerosols of henhouses in Central China.BMC microbiology · 2020Article
- Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells.Infection and immunity · 2020Article
- The Genomic Context for the Evolution and Transmission of Community-AssociatedFrontiers in microbiology · 2020Article
- Characteristics of methicillin-resistant Staphylococcus aureus from broiler farms in Germany are rather lineage- than source-specific.Poultry science · 2019Article
- Staphylococci: Evolving Genomes.Microbiology spectrum · 2019Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledUse of antimicrobials in industrial food animal production is associated with the presence of multidrug-resistant Staphylococcus aureus among animals and humans. The livestock-associated (LA) methicillin-resistant S. aureus (MRSA) clonal complex 9 (CC9) is associated with animals and related workers in Asia. This study aimed to explore the genotypic and phenotypic markers of LA-MRSA CC9 in humans. We conducted a cross-sectional study of livestock workers and controls in Guangdong, China. The study participants responded to a questionnaire and provided a nasal swab for S. aureus analysis. The resulting isolates were assessed for antibiotic susceptibility, multilocus sequence type, and immune evasion cluster (IEC) genes. Livestock workers had significantly higher rates of S. aureus CC9 (odds ratio [OR] = 30.98; 95% confidence interval [CI], 4.06 to 236.39) and tetracycline-resistant S. aureus (OR = 3.26; 95% CI, 2.12 to 5.00) carriage than controls. All 19 S. aureus CC9 isolates from livestock workers were MRSA isolates and also exhibited the characteristics of resistance to several classes of antibiotics and absence of the IEC genes. Notably, the interaction analyses indicated phenotype-phenotype (OR = 525.7; 95% CI, 60.0 to 4,602.1) and gene-environment (OR = 232.3; 95% CI, 28.7 to 1,876.7) interactions associated with increased risk for livestock-associated S. aureus CC9 carriage. These findings suggest that livestock-associated S. aureus and MRSA (CC9, IEC negative, and tetracycline resistant) in humans are associated with occupational livestock contact, raising questions about the potential for occupational exposure to opportunistic S. aureus IMPORTANCE: This study adds to existing knowledge by giving insight into the genotypic and phenotypic markers of LA-MRSA. Our findings suggest that livestock-associated S. aureus and MRSA (CC9, IEC negative, and tetracycline resistant) in humans are associated with occupational livestock contact. Future studies should direct more attention to exploring the exact transmission routes and establishing measures to prevent the spread of LA-MRSA.
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