The aetiological association between the dynamics of cortisol productivity and ADHD.

Rebecca Pinto, Fruhling Rijsdijk, Isabelle Ouellet-Morin, Philip Asherson, Grainne McLoughlin, Jonna Kuntsi

Open access · hybridAbstract readTwin Study

In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.2field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

Prenatal Stress Exposure Amplifies Effect of Maternal Suicidal Ideation on Early Childhood Behavioral Trajectories.Research on child and adolescent psychopathology · 2023
Article
Temperament Dimensions and Awakening Cortisol Levels in Attention-Deficit/Hyperactivity Disorder.Frontiers in psychiatry · 2022
Article
Disturbed relationship between glucocorticoid receptor and 5-HT1AR/5-HT2AR in ADHD rats: A correlation study.Frontiers in neuroscience · 2022
Article
Diverse Autonomic Nervous System Stress Response Patterns in Childhood Sensory Modulation.Frontiers in integrative neuroscience · 2020
Article
No evidence of associations between ADHD and event-related brain potentials from a continuous performance task in a population-based sample of adolescent twins.PloS one · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rebecca PintoKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

Fruhling RijsdijkKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

Isabelle Ouellet-MorinSchool of Criminology, University of Montréal, Research Centre of the Montreal Mental Health University Institute and the Research Group on Child Maladjustment, Montreal, Canada.

Philip AshersonKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

Grainne McLoughlinKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

Jonna KuntsiKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK. jonna.kuntsi@kcl.ac.uk.

King's College London · GBResearch Unit on Children's Psychosocial Maladjustment · CA

Funding

CIHRMedical Research Council MR/N013182/1

6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) has been linked to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, indexed by salivary cortisol. The phenotypic and aetiological association of cortisol productivity with ADHD was investigated. A selected twin design using 68 male twin-pairs aged 12-15, concordant or discordant for high ADHD symptom scores, or control twin-pairs with low ADHD symptoms, based on developmentally stable parental ADHD ratings. A genetic growth curve model was applied to cortisol samples obtained across three points during a cognitive-electroencephalography assessment, to examine the aetiological overlap of ADHD affection status (high versus low ADHD symptom scores) with latent intercept and slope factors. A significant phenotypic correlation emerged between ADHD and the slope factor, with cortisol levels dropping faster for the group with high ADHD symptom scores. The analyses further suggested this overlap was mostly driven by correlated genetic effects. We identified change in cortisol activity over time as significantly associated with ADHD affection status, primarily explained by shared genetic effects, suggesting that blunted cortisol productivity can be a marker of genetic risk in ADHD.

Indexed as

AdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildCognition DisordersCuesElectroencephalographyEvoked PotentialsHumansHydrocortisoneMaleNeuropsychological TestsPhotic StimulationPsychiatric Status Rating ScalesSalivaHydrocortisoneAttention deficit/hyperactivity disorder (ADHD)CortisolDevelopmental psychiatryGrowth curve modelling (GCM)Hypothalamic–pituitary–adrenal (HPA) axisTwin study

Identifiers

PMID27106905

DOI10.1007/s00702-016-1534-5

PMCPMC5005391

OpenAlexW2337460113

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.