Evidence map›Paper›PMID 27106597›Full record

ReviewThe Journal of physiology2017

Enteric glia: the most alimentary of all glia.

Vladimir Grubišić, Brian D Gulbransen

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Support Cells to Stem Cells: The Promise of Enteric Glia in Treating Gut Neuropathies.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  11. Calcium Imaging Studies in Enteric Glia.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  12. Review
  13. Methods to Isolate Enteric Glia from hPSC-Derived Enteric Ganglioids.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  14. Article
  15. Article
  16. Stool Glial Fibrillary Acidic Protein Is Elevated in Progressive Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vladimir GrubišićNeuroscience Program, Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI, 48824, USA.ORCID 0000-0003-1429-2844
Brian D GulbransenNeuroscience Program, Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI, 48824, USA.ORCID 0000-0003-1145-3227
Michigan State University · US

Funding

Role of enteric glia in the death of neurons during gut inflammationR01DK103723 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2015 to 2026
$4.7M
NIDDK NIH HHS R01 DK103723
6 · The paper itself

Abstract

Glia (from Greek γλοία meaning 'glue') pertains to non-neuronal cells in the central (CNS) and peripheral nervous system (PNS) that nourish neurons and maintain homeostasis. In addition, glia are now increasingly appreciated as active regulators of numerous physiological processes initially considered exclusively under neuronal regulation. For instance, enteric glia, a collection of glial cells residing within the walls of the intestinal tract, regulate intestinal motility, a well-characterized reflex controlled by enteric neurons. Enteric glia also interact with various non-neuronal cell types in the gut wall such as enterocytes, enteroendocrine and immune cells and are therefore emerging as important local regulators of diverse gut functions. The intricate molecular mechanisms that govern glia-mediated regulation are beginning to be discovered, but much remains unknown about the functions of enteric glia in health and disease. Here we present a current view of the enteric glia and their regulatory roles in gastrointestinal (GI) (patho)physiology; from GI motility and epithelial barrier function to enteric neuroinflammation.

Indexed as

AnimalsGastrointestinal MotilityHumansIntestinesNeurogliaNeurons

Identifiers

PMID27106597
PMCPMC5233670
OpenAlexW2339849544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.