ArticleNeuro-oncology2016
Restriction spectrum imaging predicts response to bevacizumab in patients with high-grade glioma.
Open access · bronzeAbstract read
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Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Restricted spectrum imaging and diffusion kurtosis imaging for assessing lymph node metastasis in cervical cancer: a histogram analysis-based study.BMC cancer · 2025Article
- TThe Iowa orthopaedic journal · 2023Article
- Linear multi-scale modeling of diffusion MRI data: A framework for characterization of oriented structures across length scales.Human brain mapping · 2023Article
- Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain.Nature communications · 2022Article
- High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 1: Perfusion and Diffusion Techniques.Frontiers in oncology · 2022Review
- Physiological Imaging Methods for Evaluating Response to Immunotherapies in Glioblastomas.International journal of molecular sciences · 2021Review
- Age and Sex Differences in the Associations of Pulse Pressure With White Matter and Subcortical Microstructure.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Associations between age and brain microstructure in older community-dwelling men and women: the Rancho Bernardo Study.Neurobiology of aging · 2020Article
- Restriction Spectrum Imaging Differentiates True Tumor Progression From Immune-Mediated Pseudoprogression: Case Report of a Patient With Glioblastoma.Frontiers in oncology · 2020Article
- The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma.Scientific reports · 2019Article
- Early assessment of recurrent glioblastoma response to bevacizumab treatment by diffusional kurtosis imaging: a preliminary report.The neuroradiology journal · 2019Article
- Diffusion MRI of cancer: From low to high b-values.Journal of magnetic resonance imaging : JMRI · 2019Review
- Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low-Grade Glioma.AJNR. American journal of neuroradiology · 2018Article
- Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab.AJNR. American journal of neuroradiology · 2018Article
- Imaging biomarkers guided anti-angiogenic therapy for malignant gliomas.NeuroImage. Clinical · 2018Review
- Quantitative analysis of neurite orientation dispersion and density imaging in grading gliomas and detectingNeuroImage. Clinical · 2018Article
- Imaging in neuro-oncology.Therapeutic advances in neurological disorders · 2018Review
- Restriction Spectrum Imaging Improves Risk Stratification in Patients with Glioblastoma.AJNR. American journal of neuroradiology · 2017Article
- Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI.Journal of magnetic resonance imaging : JMRI · 2017Review
- Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy.Epilepsia · 2016Article
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Authors and funding
14 authors at 1 institution in 1 country.
Carrie R McDonaldDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Rachel L DelfantiDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Anitha P KrishnanDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Kelly M LeydenDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Jona A Hattangadi-GluthDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Tyler M SeibertDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Roshan KarunamuniDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Pia ElbeDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Joshua M KupermanDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Hauke BartschDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
David E PiccioniDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Nathan S WhiteDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Anders M DaleDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
Nikdokht FaridDepartment of Psychiatry, University of California, San Diego, La Jolla, California (C.R.M., A.M.D.), Department of Radiology, University of California, San Diego, La Jolla, California (R.L.D., J.M.K., H.B., N.S.W., A.M.D., N.F.), Department of Radiation Medicine, University of California, San Diego, La Jolla, California (C.R.M., J.A.H.-G., T.M.S., R.K.), Department of Neurosciences, University of California, San Diego, La Jolla, California (D.E.P., A.M.D.), Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California (C.R.M., A.P.K., K.M.L., T.M.S., P.E., J.M.K., H.B., N.S.W., A.M.D., N.F.).
University of California, San Diego · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9MSan Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7MUC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4MSpatiotemporal Brain Imaging: Microscopic &System LevelR01EB000790 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2002 to 2015
$15.3MCreating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1MMultimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4MSan Diego Clinical and Translational Research InstituteKL2TR000099 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$1.1MNCATS NIH HHS KL2 TR000099NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR000100NCI NIH HHS P30 CA023100NIBIB NIH HHS R01 EB000790NIDA NIH HHS RC2 DA029475NINDS NIH HHS R01 NS065838
Abstract
backgroundDiffusion-weighted imaging has shown initial promise for evaluating response to bevacizumab in patients with high-grade glioma (HGG). However, it is well recognized that the apparent diffusion coefficient (ADC) is influenced by bevacizumab-induced reductions in edema, which may limit its prognostic value. We demonstrate that an advanced diffusion-weighted imaging technique, restriction spectrum imaging (RSI), improves the evaluation of response to bevacizumab because unlike ADC, RSI is not affected by resolution of edema.
methodsRSI and ADC maps were analyzed for 40 patients with HGG prior to and following initiation of bevacizumab. Volumes of interest were drawn for regions of contrast enhancement (CE) and fluid attenuated inversion recovery (FLAIR) hyperintensity and histogram percentiles within volumes of interest were calculated for ADC 10th percentile (ADC-CE
resultsAn increase in RSI-FLAIR
conclusionRSI is less influenced by changes in edema, conferring an advantage of RSI over ADC for evaluating response to anti-angiogenic therapy in patients with HGG.
Indexed as
AdultAgedAged, 80 and overAngiogenesis InhibitorsBevacizumabBrainBrain EdemaBrain NeoplasmsDiagnosis, Computer-AssistedDiffusion Magnetic Resonance ImagingDisease-Free SurvivalErbB ReceptorsFemaleGliomaHumansMagnetic Resonance SpectroscopyAngiogenesis InhibitorsBevacizumabEGFR protein, humanErbB Receptorsapparent diffusion coefficientbevacizumabdiffusion-weighted imaginghigh-grade gliomarestriction spectrum imaging
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