ReviewCNS drugs2016
The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects.
Review in CNS drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The Efficacy of Pharmacological Treatment of Depression in Anorexia Nervosa and Underweight Patients: A Systematic Review.European eating disorders review : the journal of the Eating Disorders Association · 2026Pooled it
- Psychosocial etiology of maladaptive exercise and its role in eating disorders: A systematic review.The International journal of eating disorders · 2021Pooled it
- The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.Psychological medicine · 2023Trial
- Olanzapine Versus Placebo in Adult Outpatients With Anorexia Nervosa: A Randomized Clinical Trial.The American journal of psychiatry · 2019Trial
- Comorbid Depression in Hospitalised Youth With Anorexia Nervosa: Characteristics, Correlates, and Impact on Weight Gain and Treatment Duration.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Nucleus accumbens deep brain stimulation in adult patients suffering from severe and enduring anorexia nervosa (STIMARS): protocol for a pilot study.Frontiers in psychiatry · 2025Article
- Pharmacotherapeutic strategies for the treatment of anorexia nervosa - novel targets to break a vicious cycle.Expert opinion on pharmacotherapy · 2024Review
- A case report of anorexia nervosa in a 23-year-old Ethiopian woman.Clinical case reports · 2023Article
- An overview of the treatment of eating disorders in adults and adolescents: pharmacology and psychotherapy.Postepy psychiatrii neurologii · 2023Review
- A retrospective study of pharmacological treatment in anorexia nervosa: 6-month and 12-month follow-up.BMC psychiatry · 2023Review
- Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa: A systematic scoping review.PloS one · 2023Article
- How Can Animal Models Inform the Understanding of Cognitive Inflexibility in Patients with Anorexia Nervosa?Journal of clinical medicine · 2022Review
- Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa.Biological psychiatry · 2021Article
- Adjunctive Clotiapine for the Management of Delusions in Two Adolescents with Anorexia Nervosa.Behavioral sciences (Basel, Switzerland) · 2021Article
- A Comprehensive Review of Complications and New Findings Associated with Anorexia Nervosa.Journal of clinical medicine · 2021Review
- Food Restriction Engages Prefrontal Corticostriatal Cells and Local Microcircuitry to Drive the Decision to Run versus Conserve Energy.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Commentary on Vulnerability and Resilience to Activity-Based Anorexia and the Role of Dopamine.Journal of experimental neurology · 2021Article
- Study Protocol for "Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study".Frontiers in psychiatry · 2021Article
- The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa.Frontiers in psychiatry · 2021Article
- Is aripiprazole a key to unlock anorexia nervosa?: A case series.Clinical case reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Anorexia nervosa (AN) is a severe psychiatric disorder without approved medication intervention. Every class of psychoactive medication has been tried to improve treatment outcome; however, randomized controlled trials have been ambiguous at best and across studies have not shown robust improvements in weight gain and recovery. Here we review the available literature on pharmacological interventions since AN came to greater public recognition in the 1960s, including a critical review of why those trials may not have been successful. We further provide a neurobiological background for the disorder and discuss how cognition, learning, and emotion-regulating circuits could become treatment targets in the future. Making every effort to develop effective pharmacological treatment options for AN is imperative as it continues to be a complex psychiatric disorder with high disease burden and mortality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.