ArticleThe Journal of allergy and clinical immunology2016
Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Pooled it
- Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation.Environmental health : a global access science source · 2018Trial
- Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts.The Journal of allergy and clinical immunology · 2018Trial
- Leveraging artificial intelligence for the management of preschool wheeze: A narrative review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Review
- Adult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.Journal of personalized medicine · 2024Article
- Social inequalities in childhood asthma.The World Allergy Organization journal · 2024Review
- Article
- SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study.Wellcome open research · 2024Article
- Clinical features and later prognosis of replicable early-life wheeze clusters from two birth cohorts 12 years apart.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Socioeconomic position, bronchiolitis and asthma in children: counterfactual disparity measures from a national birth cohort study.International journal of epidemiology · 2023Article
- Early-life and health behaviour influences on lung function in early adulthood.The European respiratory journal · 2023Article
- Early-Life Antibiotic Exposure and Childhood Asthma Trajectories: A National Population-Based Birth Cohort.Antibiotics (Basel, Switzerland) · 2023Article
- Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.American journal of respiratory and critical care medicine · 2022Article
- Review
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Endotype of allergic asthma with airway obstruction in urban children.The Journal of allergy and clinical immunology · 2021Article
- Intake ofThe European respiratory journal · 2021Article
- Risk, Mechanisms and Implications of Asthma-Associated Infectious and Inflammatory Multimorbidities (AIMs) among Individuals With Asthma: a Systematic Review and a Case Study.Allergy, asthma & immunology research · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundVariable patterns of childhood wheezing might indicate differences in the cause and prognosis of respiratory illnesses. Better understanding of these patterns could facilitate identification of modifiable factors related to development of asthma.
objectivesWe characterized childhood wheezing phenotypes from infancy to adolescence and their associations with asthma outcomes.
methodsLatent class analysis was used to derive phenotypes based on patterns of wheezing recorded at up to 14 time points from birth to 16½ years among 12,303 participants from the Avon Longitudinal Study of Parents and Children. Measures of lung function (FEV
resultsSix wheezing phenotypes were identified: never/infrequent, preschool-onset remitting, midchildhood-onset remitting, school age-onset persisting, late childhood-onset persisting, and continuous wheeze. The 3 persistent phenotypes were associated with bronchodilator reversibility of 12% or greater (BDR) from baseline (odds ratio [OR] range, 2.14-3.34), a Feno value of 35 ppb or greater (OR range, 3.82-6.24), and lung function decrements (mean range of differences: -0.22 to -0.27 SD units (SDU) for FEV
conclusionsEarly childhood-onset wheezing that persists into adolescence represents the clearest target group for interventions to maximize lung function outcomes.
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