ArticleNucleic acids research2016
SensiPath: computer-aided design of sensing-enabling metabolic pathways.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Autocatalytic selection of gene functions in synthetic cells.Communications biology · 2026Article
- Programming Next-Generation Synthetic Biosensors by Genetic Circuit Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- groovDB in 2026: a community-editable database of small molecule biosensors.Nucleic acids research · 2026Article
- Biological Switches: Past and Future Milestones of Transcription Factor-Based Biosensors.ACS synthetic biology · 2025Review
- Microbial biosensors for diagnostics, surveillance and epidemiology: Today's achievements and tomorrow's prospects.Microbial biotechnology · 2024Review
- DetSpace: a web server for engineering detectable pathways for bio-based chemical production.Nucleic acids research · 2024Article
- Snowprint: a predictive tool for genetic biosensor discovery.Communications biology · 2024Article
- Article
- Accelerating Genetic Sensor Development, Scale-up, and Deployment Using Synthetic Biology.Biodesign research · 2024Article
- TFBMiner: A User-Friendly Command Line Tool for the Rapid Mining of Transcription Factor-Based Biosensors.ACS synthetic biology · 2023Article
- Sensbio: an online server for biosensor design.BMC bioinformatics · 2023Article
- Transcription factor-based biosensors for screening and dynamic regulation.Frontiers in bioengineering and biotechnology · 2023Review
- Prediction of degradation pathways of phenolic compounds in the human gut microbiota through enzyme promiscuity methods.NPJ systems biology and applications · 2022Article
- Research progress of pathway and genome evolution in microbes.Synthetic and systems biotechnology · 2022Article
- Rhea, the reaction knowledgebase in 2022.Nucleic acids research · 2022Article
- Cell-Free Biosensors and AI Integration.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A small-molecule chemical interface for molecular programs.Nucleic acids research · 2021Article
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- Extended Metabolic Biosensor Design for Dynamic Pathway Regulation of Cell Factories.iScience · 2020Article
- Evolution-guided engineering of small-molecule biosensors.Nucleic acids research · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Genetically-encoded biosensors offer a wide range of opportunities to develop advanced synthetic biology applications. Circuits with the ability of detecting and quantifying intracellular amounts of a compound of interest are central to whole-cell biosensors design for medical and environmental applications, and they also constitute essential parts for the selection and regulation of high-producer strains in metabolic engineering. However, the number of compounds that can be detected through natural mechanisms, like allosteric transcription factors, is limited; expanding the set of detectable compounds is therefore highly desirable. Here, we present the SensiPath web server, accessible at http://sensipath.micalis.fr SensiPath implements a strategy to enlarge the set of detectable compounds by screening for multi-step enzymatic transformations converting non-detectable compounds into detectable ones. The SensiPath approach is based on the encoding of reactions through signature descriptors to explore sensing-enabling metabolic pathways, which are putative biochemical transformations of the target compound leading to known effectors of transcription factors. In that way, SensiPath enlarges the design space by broadening the potential use of biosensors in synthetic biology applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.