ArticleSchizophrenia bulletin2016
Motivational Context Modulates Prediction Error Response in Schizophrenia.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neurofunctional representations of instrumental learning in psychosis: a meta-analysis of neuroimaging studies.Psychological medicine · 2025Pooled it
- Abnormal prediction error processing in schizophrenia and depression.Human brain mapping · 2021Pooled it
- Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia.Human brain mapping · 2018Pooled it
- Depression Levels Are Associated with Reduced Capacity to Learn to Actively Avoid Aversive Events in Young Adults.eNeuro · 2025Article
- Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis.Psychological medicine · 2025Article
- Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis.Biological psychiatry global open science · 2025Article
- Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia.Translational psychiatry · 2024Article
- Belief Updating in Subclinical and Clinical Delusions.Schizophrenia bulletin open · 2023Article
- Both unmedicated and medicated individuals with schizophrenia show impairments across a wide array of cognitive and reinforcement learning tasks.Psychological medicine · 2022Article
- Reduced learning bias towards the reward context in medication-naive first-episode schizophrenia patients.BMC psychiatry · 2022Article
- Differential reinforcement learning responses to positive and negative information in unmedicated individuals with depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Psychiatric symptoms influence reward-seeking and loss-avoidance decision-making through common and distinct computational processes.Psychiatry and clinical neurosciences · 2021Article
- Reinforcement learning abnormalities in the attenuated psychosis syndrome and first episode psychosis.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Reliability and Replicability of Implicit and Explicit Reinforcement Learning Paradigms in People With Psychotic Disorders.Schizophrenia bulletin · 2021Article
- Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients.Schizophrenia bulletin · 2020Article
- Cingulum and abnormal psychological stress response in schizophrenia.Brain imaging and behavior · 2020Article
- From neuroimaging to daily functioning: A multimethod analysis of reward anticipation in people with schizophrenia.Journal of abnormal psychology · 2019Article
- Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Reduced Neural Sensitivity to Social vs Nonsocial Reward in Schizophrenia.Schizophrenia bulletin · 2019Article
- Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals.Cognitive, affective & behavioral neuroscience · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundRecent findings demonstrate that patients with schizophrenia are worse at learning to predict rewards than losses, suggesting that motivational context modulates learning in this disease. However, these findings derive from studies in patients treated with antipsychotic medications, D2 receptor antagonists that may interfere with the neural systems that underlie motivation and learning. Thus, it remains unknown how motivational context affects learning in schizophrenia, separate from the effects of medication.
methodsTo examine the impact of motivational context on learning in schizophrenia, we tested 16 unmedicated patients with schizophrenia and 23 matched controls on a probabilistic learning task while they underwent functional magnetic resonance imaging (fMRI) under 2 conditions: one in which they pursued rewards, and one in which they avoided losses. Computational models were used to derive trial-by-trial prediction error responses to feedback.
resultsPatients performed worse than controls on the learning task overall, but there were no behavioral effects of condition. FMRI revealed an attenuated prediction error response in patients in the medial prefrontal cortex, striatum, and medial temporal lobe when learning to predict rewards, but not when learning to avoid losses.
conclusionsPatients with schizophrenia showed differences in learning-related brain activity when learning to predict rewards, but not when learning to avoid losses. Together with prior work, these results suggest that motivational deficits related to learning in schizophrenia are characteristic of the disease and not solely a result of antipsychotic treatment.
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