ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Epidemiology of Invasive Group A Streptococcal Infections in the United States, 2005-2012.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 3 of them syntheses that pooled it.
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Who cites it
228 citing papers in PubMed, 3 syntheses or guidelines pooled it, 405 citations in OpenAlex.
- Antibiotic synergy againstAntimicrobial agents and chemotherapy · 2025Pooled it
- Group A Streptococcal meningitis in children: a short case series and systematic review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Pooled it
- Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis.BMJ open · 2022Pooled it
- Trial
- Epidemiology of Pediatric Invasive Group A Streptococcal Infections in 10 US States, 2004-2023.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Predominance of M1European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Sudden re-emergence ofNew microbes and new infections · 2026Article
- Ischemic dermal pallor as an unusual cutaneous clue for group A streptococcal necrotizing soft tissue infection.JAAD case reports · 2026Article
- Burden of invasive group a streptococcus infection in Australia: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Pregnancy-Related Mortality Due to Infection: Maternal Mortality Review Committees in 29 U.S. States, 2017-2019.Obstetrics and gynecology · 2026Article
- Epidemiology and clinical characteristics of invasive group A streptococcal infection in the Republic of Korea, 2015-2024: a nationwide multicenter study.The Lancet regional health. Western Pacific · 2026Article
- Increased burden of invasive group A streptococcal disease among Australian children, 2023-2024: a prospective cohort study.The Lancet regional health. Western Pacific · 2026Article
- Before and after the bottleneck: pediatric group A streptococcal infections in Houston, TX, from 2013 to 2023.Microbiology spectrum · 2026Article
- Intravenous non-specific immunoglobulins as adjunctive therapy for invasiveRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Observational
- Invasive Group A Streptococcal Disease in Persons Experiencing Postpandemic Homelessness in Canada.JAMA network open · 2026Article
- Molecular epidemiology and antimicrobial susceptibility of group A Streptococcus isolated from children in Greece during 2023.Infection · 2026Article
- [Research progress on toxic shock syndrome due to group AZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data.BMC medicine · 2026Article
- T cells in Group AFrontiers in cellular and infection microbiology · 2026Review
- Fulminant streptococcal toxic shock syndrome presenting as cervical epidural abscess: a case report.Journal of Yeungnam medical science · 2026Article
168 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundInvasive group A Streptococcus (GAS) infections are associated with significant morbidity and mortality rates. We report the epidemiology and trends of invasive GAS over 8 years of surveillance.
methodsFrom January 2005 through December 2012, we collected data from the Centers for Disease Control and Prevention's Active Bacterial Core surveillance, a population-based network of 10 geographically diverse US sites (2012 population, 32.8 million). We defined invasive GAS as isolation of GAS from a normally sterile site or from a wound in a patient with necrotizing fasciitis (NF) or streptococcal toxic shock syndrome (STSS). Available isolates were emm typed. We calculated rates and made age- and race-adjusted national projections using census data.
resultsWe identified 9557 cases (3.8 cases per 100 000 persons per year) with 1116 deaths (case-fatality rate, 11.7%). The case-fatality rates for septic shock, STSS, and NF were 45%, 38%, and 29%, respectively. The annual incidence was highest among persons aged ≥65 years (9.4/100 000) or <1 year (5.3) and among blacks (4.7/100 000). National rates remained steady over 8 years of surveillance. Factors independently associated with death included increasing age, residence in a nursing home, recent surgery, septic shock, NF, meningitis, isolated bacteremia, pneumonia, emm type 1 or 3, and underlying chronic illness or immunosuppression. An estimated 10 649-13 434 cases of invasive GAS infections occur in the United States annually, resulting in 1136-1607 deaths. In a 30-valent M-protein vaccine, emm types accounted for 91% of isolates.
conclusionsThe burden of invasive GAS infection in the United States remains substantial. Vaccines under development could have a considerable public health impact.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.