Evidence map›Paper›PMID 27105330›Full record

ArticleJournal of lower genital tract disease2016

Impact of Physical Inactivity on Risk of Developing Cancer of the Uterine Cervix: A Case-Control Study.

James Brian Szender, Rikki Cannioto, Nicolas R Gulati, Kristina L Schmitt, Grace Friel, Albina Minlikeeva, Alexis Platek, Emily H Gower, Ryan Nagy, Edgar Khachatryan and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of lower genital tract disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Physical Inactivity and Pancreatic Cancer Mortality.Journal of gastrointestinal cancer · 2020
    Article
  10. Article
  11. Article
  12. The association of lifetime physical inactivity with head and neck cancer: a hospital-based case-control analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

James Brian Szender1Department of Gynecologic Oncology, Roswell Park Cancer Institute; 2Department of Epidemiology and Environmental Health, State University of New York at Buffalo; 3Department Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo; 4Department of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY; 5College of Medicine, Lake Erie College of Osteopathic Medicine, Erie, PA; 6Independent Health; 7Department of Health Behavior, Roswell Park Cancer Institute; and 8Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY.
Rikki Cannioto
Nicolas R Gulati
Kristina L Schmitt
Grace Friel
Albina Minlikeeva
Alexis Platek
Emily H Gower
Ryan Nagy
Edgar Khachatryan
Paul C Mayor
Karin A Kasza
Shashikant B Lele
Kunle Odunsi
Kirsten B Moysich
Roswell Park Comprehensive Cancer Center · USGynecologic Oncology Group · USLake Erie College of Osteopathic Medicine · USOldham Council · GBRochester Institute of Technology · USUniversity at Buffalo, State University of New York · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6M
Postdoctoral Research Training in Surgical OncologyT32CA108456 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI YENDAMURI, SAIKRISHNA · 2006 to 2020
$2.8M
Interdisciplinary Training in Cancer Epidemiology at UBR25CA113951 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FREUDENHEIM, JO L., MOYSICH, KIRSTEN B. · 2007 to 2016
$2.5M
NCI NIH HHS P30 CA016056NCI NIH HHS P50 CA159981NCI NIH HHS R25 CA113951NCI NIH HHS T32 CA108456
6 · The paper itself

Abstract

objectiveIn this study, we investigated whether physical inactivity was associated with risk of cervical cancer in women treated at an American cancer hospital.

methodsThis case-control study included 128 patients with cervical cancer and 512 controls matched on age. Controls were women suspected of having but not ultimately diagnosed with a neoplasm. Physical inactivity was defined in accordance with the 2008 Physical Activity Guidelines for Americans. Thus, participants reporting, on average, no moderate or vigorous recreational physical activity were classified as inactive. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

resultsCompared with noncancer controls, those with cervical cancer had significantly increased odds of reporting abstinence from recreational physical activity (OR, 2.43; 95% CI, 1.56-3.80). No association was noted between occupational-related physical inactivity and cervical cancer (OR, 0.88; 95% CI, 0.58-1.36).

conclusionsOur findings suggest that abstinence from regular recreational physical activity is associated with increased odds of cervical cancer. To our knowledge, this is the first US-based study examining these associations. Given the 2008 Physical Activity Guidelines for Americans, this study has identified yet another potential public health benefit to regular physical activity. Further investigation is needed using a larger sample and prospectively collected data to characterize dose of activity to mitigate risk and the optimal window of susceptibility.

Indexed as

ExerciseAdultCase-Control StudiesFemaleHumansRisk AssessmentUterine Cervical NeoplasmsYoung Adult

Identifiers

PMID27105330
PMCPMC4920713
OpenAlexW2336227953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.