Evidence map›Paper›PMID 27105171›Full record

ArticlePsychiatric genetics2016

Cognitive profiles and heritability estimates in the Old Order Amish.

Ryan M Kuehner, Peter Kochunov, Katie L Nugent, Deanna E Jurius, Anya Savransky, Christopher Gaudiot, Heather A Bruce, James Gold, Alan R Shuldiner, Braxton D Mitchell and 1 more

Open access · greenAbstract read
In one paragraph

Article in Psychiatric genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ryan M KuehneraDepartment of Professional Counseling and Social Work, Capital Seminary and Graduate School/Lancaster Bible College, Lancaster, Pennsylvania bDepartment of Psychiatry, Maryland Psychiatric Research Center cDepartment of Medicine, University of Maryland School of Medicine dDepartment of Veterans Affairs, Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center (GRECC), Baltimore, Maryland, USA.
Peter Kochunov
Katie L Nugent
Deanna E Jurius
Anya Savransky
Christopher Gaudiot
Heather A Bruce
James Gold
Alan R Shuldiner
Braxton D Mitchell
L Elliot Hong
University of Maryland, Baltimore · USGeriatric Research Education and Clinical Center · USLancaster Bible College · US

Funding

The Effects of Kynurenine Aminotransferase Inhibition in People with SchizophreniaP50MH103222 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHWARCZ, ROBERT · 2014 to 2023
$25.2M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Multidisciplinary Schizophrenia Research TrainingT32MH067533 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CARPENTER, WILLIAM T., ELMER, GREGORY I · 2004 to 2025
$4.3M
Amish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3M
Shared Neural Circuitry in Comorbid Schizophrenia and Nicotine AddictionR01DA027680 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2010 to 2014
$2.4M
Neural Oscillatory Biomarkers for Genetics and Animal Models of SchizophreniaR01MH085646 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2010 to 2013
$2.2M
NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA027680NIMH NIH HHS P50 MH103222NIMH NIH HHS R01 MH085646NIMH NIH HHS T32 MH067533NIMH NIH HHS U01 MH108148
6 · The paper itself

Abstract

objectiveThis study aimed to establish the applicability of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in the Old Order Amish (OOA) and to assess the genetic contribution toward the RBANS total score and its cognitive domains using a large family-based sample of OOA. PARTICIPANTS AND

methodsRBANS data were collected in 103 OOA individuals from Lancaster County, Pennsylvania, including 85 individuals without psychiatric illness and 18 individuals with current psychiatric diagnoses.

resultsThe RBANS total score and all five cognitive domains of in nonpsychiatric OOA were within half a SD of the normative data of the general population. The RBANS total score was highly heritable (h=0.51, P=0.019). OOA with psychiatric diagnoses had a numerically lower RBANS total score and domain scores compared with the nonpsychiatric participants.

conclusionThe RBANS appears to be a suitable cognitive battery for the OOA population as measurements obtained from the OOA are comparable with normative data in the US population. The heritability estimated from the OOA is in line with heritabilities of other cognitive batteries estimated in other populations. These results support the use of RBANS in cognitive assessment, clinical care, and behavioral genetic studies of neuropsychological functioning in this population.

Indexed as

AdultAmishCognitionCognition DisordersFemaleHumansMaleMiddle AgedNeuropsychological TestsPennsylvaniaPsychometricsReproducibility of Results

Identifiers

PMID27105171
PMCPMC5241270
OpenAlexW2337562345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.