Evidence map›Paper›PMID 27105111›Full record

ArticleMolecular cell2016

Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements.

Diana C Cox, Thomas A Cooper

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Lack of RAN-mediated toxicity in Huntington's disease knock-in mice.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Diana C CoxDepartments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Thomas A CooperDepartments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: tcooper@bcm.edu.

Funding

MOLECULAR PATHOGENESIS OF MYOTONIC DYSTROPHYR01AR045653 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 1999 to 2018
$8.3M
TROPONIN T ALTERNATIVE SPLICING IN EMBRYONIC HEARTR01HL045565 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 1996 to 2018
$5.5M
Transcriptome processing networks in skeletal muscle: mechanisms and functionsR01AR060733 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 2011 to 2023
$4.0M
NHLBI NIH HHS R01 HL045565NIAMS NIH HHS R01 AR045653NIAMS NIH HHS R01 AR060733
6 · The paper itself

Abstract

Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.

Indexed as

AtaxiaFragile X SyndromeFragile X Messenger Ribonucleoprotein 1HumansTremorFragile X Messenger Ribonucleoprotein 1

Identifiers

PMID27105111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.