Evidence map›Paper›PMID 27105048›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2016

Randomized Factorial Trial of Phone-Delivered Support Counseling and Daily Text Message Reminders for HIV Treatment Adherence.

Seth C Kalichman, Moira O Kalichman, Chauncey Cherry, Lisa A Eaton, Dean Cruess, Raymond F Schinazi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04577313 (DOSE DETERMINATION TRIAL), which is not on this map. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04577313 narecruitingnot on this mapstarted 2020, after this paper: background citation

DOSE DETERMINATION TRIAL: The Start/Persist Studies

TypeinterventionalSponsorUniversity of ConnecticutRan2020 to 2026Enrolled400ConditionsHIV InfectionsArmsBehavioral Self-Regulation Adherence Counseling
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Seth C Kalichman*Department of Psychology, University of Connecticut, Storrs, CT; and †Center for AIDS Research, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, GA.
Moira O Kalichman
Chauncey Cherry
Lisa A Eaton
Dean Cruess
Raymond F Schinazi
University of Connecticut · USEmory University · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Nurse Delivered Cell-Phone HIV Adherence InterventionR01NR012962 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2011 to 2015
$2.6M
NIAID NIH HHS P30 AI050409NINR NIH HHS R01 NR012962
6 · The paper itself

Abstract

backgroundHIV infection is clinically managed with antiretroviral therapy (ART), but only with sustained adherence. Cost-efficient interventions to improve and sustain ART adherence remain a pressing priority for populations challenged by nonadherence. The aim of this study was to test the independent and interactive effects of (1) brief phone-delivered self-regulation counseling and (2) daily phone-delivered text message medication reminders on HIV adherence and HIV viral suppression.

methodA randomized 2 (5 sessions of phone-delivered adherence support counseling vs. contact-matched control) × 2 (daily ART text reminders vs. no reminders) trial with primary end points of monthly phone-based unannounced pill count-determined ART adherence and HIV viral suppression monitored over 12 months.

resultsSelf-regulation adherence counseling demonstrated significant improvements in achieving 90% ART adherence relative to the control group over the first 6 months of follow-up. Effects remained significant in sensitivity analyses conducted at 85% and 95% adherence. Counseling also demonstrated modest but significant effects on HIV suppression. There were no main effects or interactions for daily text message reminders, with some evidence for adverse effects on adherence self-efficacy.

conclusionsBrief adherence support counseling delivered by phone demonstrates clinically meaningful improvements in ART adherence and HIV suppression, although these benefits were not evidenced in all patients or in the long-term. Advancing adherence interventions along with an effective means for sustaining gains in adherence remain priorities if ART is to achieve its potential clinical and public health benefits.

Indexed as

CounselingPatient ComplianceReminder SystemsText MessagingAnti-HIV AgentsFemaleGeorgiaHIV InfectionsHumansMaleModels, PsychologicalSelf EfficacyViral LoadAnti-HIV Agents

Identifiers

PMID27105048
PMCPMC4981529
OpenAlexW2338373450

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.