ArticleCell2016
Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed.
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- Condenzymes: Biomolecular condensates with inherent catalytic activities.bioRxiv : the preprint server for biology · 2025Article
- Self-organization of active plume lattice in bacterial bioconvection.Quantitative biology (Beijing, China) · 2025Article
- Partitioning of a 2-bit hash function across 66 communicating cells.Nature chemical biology · 2025Article
- Intrinsically robust and scalable biofilm segmentation under diverse physical growth conditions.iScience · 2024Article
- AI in cellular engineering and reprogramming.Biophysical journal · 2024Review
- Dynamical model of antibiotic responses linking expression of resistance genes to metabolism explains emergence of heterogeneity during drug exposures.Physical biology · 2024Article
- Bridging the gap between mechanistic biological models and machine learning surrogates.PLoS computational biology · 2023Review
- Spatiotemporal Patterning Enabled by Gene Regulatory Networks.ACS omega · 2023Article
- Guided by the principles of microbiome engineering: Accomplishments and perspectives for environmental use.mLife · 2022Review
- Stress anisotropy in confined populations of growing rods.Journal of the Royal Society, Interface · 2022Article
- Self-organized canals enable long-range directed material transport in bacterial communities.eLife · 2022Article
- Engineering microbial consortia with rationally designed cellular interactions.Current opinion in biotechnology · 2022Review
- Engineered Living Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Advances and challenges in programming pattern formation using living cells.Current opinion in chemical biology · 2022Review
- Synthetic spatial patterning in bacteria: advances based on novel diffusible signals.Microbial biotechnology · 2022Review
- Synthetic Morphogenesis: introducing IEEE journal readers to programming living mammalian cells to make structures.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2022Article
- Modulation of microbial community dynamics by spatial partitioning.Nature chemical biology · 2022Article
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6 authors.
Funding
Abstract
Scale invariance refers to the maintenance of a constant ratio of developing organ size to body size. Although common, its underlying mechanisms remain poorly understood. Here, we examined scaling in engineered Escherichia coli that can form self-organized core-ring patterns in colonies. We found that the ring width exhibits perfect scale invariance to the colony size. Our analysis revealed a collective space-sensing mechanism, which entails sequential actions of an integral feedback loop and an incoherent feedforward loop. The integral feedback is implemented by the accumulation of a diffusive chemical produced by a colony. This accumulation, combined with nutrient consumption, sets the timing for ring initiation. The incoherent feedforward is implemented by the opposing effects of the domain size on the rate and duration of ring maturation. This mechanism emphasizes a role of timing control in achieving robust pattern scaling and provides a new perspective in examining the phenomenon in natural systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.