ReviewAnnals of the American Thoracic Society2016
Frailty in Pulmonary and Critical Care Medicine.
Review in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03636412 (Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- The impact of frailty on clinical outcomes among individuals with COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Pulmonary Rehabilitation Exercise Package for Enhancing Health in Elderly COPD Patients With Frailty: An Experimental Study.The journal of nursing research : JNR · 2025Trial
- The Association between Prehospital Vulnerability, ARDS Development, and Mortality among At-Risk Adults. Results from the LIPS-A Clinical Trial.Annals of the American Thoracic Society · 2019Trial
- Frailty in Pulmonary Arterial Hypertension: A Cohort Study.Annals of the American Thoracic Society · 2026Article
- Functional Predictors of Frailty and Kidney Disease Burden in Patients with End-stage Renal Disease Receiving Dialysis.Journal of frailty, sarcopenia and falls · 2026Article
- Predictive value of bedside lung ultrasound, quantitative chest CT, and frailty assessment for short-term outcomes in elderly patients with severe pneumonia: a pilot study.BMC pulmonary medicine · 2025Article
- Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area.Scientific reports · 2024Article
- Bjørn Ibsen: What Made Intensive Care So Critical?Cureus · 2024Review
- The Long-Term Impact of Frailty After an Intensive Care Unit Admission Due to Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Comprehensive analysis of vulnerability status and associated affect factors among prehospital emergency patients: a single-center descriptive cross-sectional study.Frontiers in public health · 2024Article
- Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients.Frontiers in transplantation · 2024Review
- Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2023Article
- The modified 5-item frailty index as a predictor of complications in burn patients.JPRAS open · 2023Article
- Subphenotypes of frailty in lung transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Clin-STAR corner: Recent practice-changing studies at the interface of pulmonary and critical care medicine and geriatrics.Journal of the American Geriatrics Society · 2023Article
- The impact of frailty on death, discharge destination and modelling accuracy in patients receiving organ support on the intensive care unit.Journal of the Intensive Care Society · 2023Article
- Is Frailty Diagnosis Important in Patients with COPD? A Narrative Review of the Literature.International journal of environmental research and public health · 2023Review
- Body Composition and COPD: A New Perspective.International journal of chronic obstructive pulmonary disease · 2023Review
- Frailty and Mortality Risk in COPD: A Cohort Study Comparing the Fried Frailty Phenotype and Short Physical Performance Battery.International journal of chronic obstructive pulmonary disease · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Conceptualized first in the field of geriatrics, frailty is a syndrome characterized by a generalized vulnerability to stressors resulting from an accumulation of physiologic deficits across multiple interrelated systems. This accumulation of deficits results in poorer functional status and disability. Frailty is a "state of risk" for subsequent disproportionate declines in health status following new exposure to a physiologic stressor. Two predominant models have emerged to operationalize the measurement of frailty. The phenotype model defines frailty as a distinct clinical syndrome that includes conceptual domains such as strength, activity, wasting, and mobility. The cumulative deficit model defines frailty by enumerating the number of age-related things wrong with a person. The biological pathways driving frailty include chronic systemic inflammation, sarcopenia, and neuroendocrine dysregulation, among others. In adults with chronic lung disease, frailty is independently associated with more frequent exacerbations of lung disease, all-cause hospitalization, declines in functional status, and all-cause mortality. In addition, frail adults who become critically ill are more likely develop chronic critical illness or severe disability and have higher in-hospital and long-term mortality rates. The evaluation of frailty appears to provide important prognostic information above and beyond routinely collected measures in adults with chronic lung disease and the critically ill. The study of frailty in these populations, however, requires multipronged efforts aimed at refining clinical assessments, understanding the mechanisms, and developing therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.