ReviewThe Journal of physiology2016
Renal extracellular vesicles: from physiology to clinical application.
Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Urinary Extracellular Vesicles Biomarkers in CKD: Clinical Laboratory Translation.Diagnostics (Basel, Switzerland) · 2026Review
- Urinary extracellular vesicle proteins for biomarker discovery in chronic kidney disease.Kidney research and clinical practice · 2026Article
- Urinary microvesicles: a window into the kidney.Clinical kidney journal · 2025Review
- Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases.Journal of nanobiotechnology · 2025Review
- Role of Exosomes in Cardiovascular Diseases.Reviews in cardiovascular medicine · 2024Review
- Hands-Free Proteomic Profiling of Urinary Extracellular Vesicles with a High-Throughput Automated Workflow.Journal of the American Society for Mass Spectrometry · 2023Article
- Oral Potassium Supplementation Flicks the Renal K-Switch in Humans.Kidney international reports · 2023Article
- Platelet-Derived Exosomes and Atherothrombosis.Frontiers in cardiovascular medicine · 2022Review
- Reduced urinary release of AQP1- and AQP2-bearing extracellular vesicles in patients with advanced chronic kidney disease.Physiological reports · 2021Article
- Current Methods for the Isolation of Urinary Extracellular Vesicles.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Higher Urine Exosomal miR-193a Is Associated With a Higher Probability of Primary Focal Segmental Glomerulosclerosis and an Increased Risk of Poor Prognosis Among Children With Nephrotic Syndrome.Frontiers in cell and developmental biology · 2021Article
- Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease.Journal of extracellular vesicles · 2020Article
- Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury.Kidney diseases (Basel, Switzerland) · 2020Article
- New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis.Frontiers in physiology · 2020Review
- Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles FromFrontiers in cellular and infection microbiology · 2020Article
- Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls.American journal of physiology. Renal physiology · 2019Article
- Exosomes in Coronary Artery Disease.International journal of biological sciences · 2019Review
- Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Diseases.Frontiers in physiology · 2019Review
- Roles for Exosome in Various Kidney Diseases and Disorders.Frontiers in pharmacology · 2019Review
- [Value of podocalyxin levels in urinary extracellular vesicles for diagnosis of diabetic nephropathy].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Urinary extracellular vesicles (uEVs) are released from all regions of the kidney's nephron and from other cells that line the urinary tract. Extracellular vesicles retain proteomic and transcriptomic markers specific to their cell of origin and so represent a potential reservoir for kidney disease biomarker discovery. Exosomes, a subtype of uEVs, are distinguished from other vesicles by features related to their biogenesis within cells: mature multi-vesicular bodies fuse with the cellular membrane to liberate exosomes into the extracellular space. uEVs represent a novel cell signalling mechanism because they can be shuttled to a recipient cell and, through a number of proposed mechanisms, affect the recipient cell's proteome and function. Here we review the current evidence for uEV signalling along the nephron, their role in health and disease of the kidney, and their potential for clinical translation as biomarkers and therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.