ArticleNutrients2016
Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A Systematic Review of the Biological Effects of Cordycepin.Molecules (Basel, Switzerland) · 2021Pooled it
- Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis.Animal models and experimental medicine · 2026Article
- Selenium-Containing Nano-Micelles Delay the Cellular Senescence of BMSCs Under Oxidative Environment and Maintain Their Regenerative Capacity.Bioengineering (Basel, Switzerland) · 2025Article
- Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration.International journal of oral science · 2025Article
- Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model.Food science & nutrition · 2024Article
- Effect ofMolecules (Basel, Switzerland) · 2022Review
- Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal · 2022Article
- Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS.Bioactive materials · 2021Article
- Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response.Experimental & molecular medicine · 2021Article
- Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss.Frontiers in pharmacology · 2020Article
- A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin.Scientific reports · 2019Article
- Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi.Molecules (Basel, Switzerland) · 2019Review
- Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.Nature communications · 2019Article
- SiBaoChongCao exhibited anti-fatigue activities and ameliorated cancer cachexia in mice.RSC advances · 2019Article
- The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.Scientific reports · 2019Article
- Graphene-Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoEOncotarget · 2017Article
- Osthole Enhances Osteogenesis in Osteoblasts by Elevating Transcription Factor Osterix via cAMP/CREB Signaling In Vitro and In Vivo.Nutrients · 2017Article
- Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen.Neural plasticity · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cordycepin was previously reported to have anti-tumor, anti-inflammatory and anti-oxidant activity. However, the potential role of cordycepin in bone metabolism and cell biology of osteoclasts remains unclear. In our study, we focused on the in vitro effects of cordycepin on osteoclastogenesis and its in vivo effects in ovariectomized (OVX) mice. Osteoclast differentiation, formation and fusion were evaluated by Tartrate-resistant acid phosphatase (TRAP) stain, focal adhesion stain and fusion assay, respectively. Osteoclastic bone resorption was evaluated by pit formation assay. Reactive oxygen species (ROS) generation and removal were detected by the ROS assay. OVX mice were orally administered with 10 mg/kg of cordycepin daily for four weeks. In vitro results revealed that cordycepin inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation, formation, fusion and bone resorption activity. We further proved that cordycepin treatments scavenged the generation of ROS, upregulated interferon regulatory factor 8 (IRF-8) and suppressed the activity of nuclear factor of activated T cells c1 (NFATc1) during osteoclastogenesis. In vivo results indicated cordycepin prevents bone loss, rescues bone microarchitecture, and restores bone mineralization in OVX mice. Our observations strongly suggested that cordycepin is an efficient osteoclast inhibitor and hold potential therapeutic value in preventing bone loss among postmenopausal osteoporosis patients.
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