ReviewJournal of diabetes and metabolic disorders2015
Likelihood ratio of computed tomography characteristics for diagnosis of malignancy in adrenal incidentaloma: systematic review and meta-analysis.
Review in Journal of diabetes and metabolic disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reliability of CT attenuation value for adrenal masses.Endocrine connections · 2026Article
- Changing paradigms in evaluating adrenal incidentalomas: Bayesian evaluation of [World journal of clinical oncology · 2025Review
- Diagnosis and management of adrenal incidentaloma: use of clinical judgment and evidence in dialog with the patient.Surgery today · 2024Review
- [Neurofibromatosis type 1 associated with pheochromocytoma: a case report with a brief review of the literature].Problemy endokrinologii · 2023Review
- Stereotactic radiotherapy for adrenal oligometastases.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Review
- Attenuation Value in Adrenal Incidentalomas: A Longitudinal Study.Frontiers in endocrinology · 2021Article
- WFUMB position paper on the management incidental findings: adrenal incidentaloma.Ultrasonography (Seoul, Korea) · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo propose an evidence based diagnostic algorithm using mass characteristics to determine malignancy in patients with adrenal incidentaloma by CTscan.
methodsA systematic review in Medline, Scopus, relevant reference books and desk searching was performed up to January 2016 with relevant reference checking. The summery estimates of sensitivity, specificity, positive and negative likelihood ratio of different characteristics were calculated in two groups of the articles investigating the cases without previous malignancy and the articles investigating the oncologic cases.
resultsThirty six articles were included in this study. In the first group with no history of malignancy a positive and negative LR of 3.1 and 0.13 in 4 cm threshold and positive and negative LR of 2.85 and 0 in 10HU density were found. In the second group with history of malignancy positive and negative LR of 2.3 and 0.27 in 3 cm threshold and positive and negative LR of 3.6 and 0.08 in 20HU density were resulted.
conclusionThe results retrieved in this study considering the limitations show that adrenal incidentaloma with a size less than 4 cm or a mass larger than 4 cm with density less than 10HU in the first group can be managed with imaging follow up. For masses larger than 4 cm with density more than 10HU another diagnostic procedure should be performed. In the second group an adrenal mass larger than 3 cm or less than 3 cm with density more than 20HU should go under operation. But masses smaller than 3 cm with less than 20HU density can be followed by imaging.
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