ArticleRadiation oncology journal2016
A feasibility study evaluating the relationship between dose and focal liver reaction in stereotactic ablative radiotherapy for liver cancer based on intensity change of Gd-EOB-DTPA-enhanced magnetic resonance images.
Article in Radiation oncology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 16 citations in OpenAlex.
- High dose proton and photon-based radiation therapy for 213 liver lesions: a multi-institutional dosimetric comparison with a clinical perspective.La Radiologia medica · 2024Article
- Liver parenchymal changes detected by MR elastography and diffusion-weighted imaging after stereotactic body radiotherapy for hepatocellular carcinoma.Abdominal radiology (New York) · 2023Article
- Liver magnetic resonance imaging for evaluation of response to treatment after stereotactic body radiation therapy of hepatocellular carcinoma.World journal of hepatology · 2022Article
- Direct visualization and correlation of liver stereotactic body radiation therapy treatment delivery accuracy with interfractional motion.Journal of applied clinical medical physics · 2021Article
- Stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of liver metastases in oligometastatic patients: initial clinical experience.Radiation oncology journal · 2021Article
- Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy.Physics and imaging in radiation oncology · 2021Article
- Structure guided deformable image registration for treatment planning CT and post stereotactic body radiation therapy (SBRT) PrimovistJournal of applied clinical medical physics · 2019Article
- Is higher dose always the right answer in stereotactic body radiation therapy for small hepatocellular carcinoma?Radiation oncology journal · 2018Article
- Initial clinical outcomes of proton beam radiotherapy for hepatocellular carcinoma.Radiation oncology journal · 2018Article
- MRI-based radiotherapy planning method using rigid image registration technique combined with outer body correction scheme: a feasibility study.Oncotarget · 2017Article
- Evaluation of Threshold Dose of Damaged Hepatic Tissue After Carbon-Ion Radiation Therapy Using Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging.Advances in radiation oncologyArticle
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5 authors at 2 institutions in 1 country.
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Abstract
purposeIn order to evaluate the relationship between the dose to the liver parenchyma and focal liver reaction (FLR) after stereotactic ablative body radiotherapy (SABR), we suggest a novel method using a three-dimensional dose distribution and change in signal intensity of gadoxetate disodium-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) hepatobiliary phase images. MATERIALS AND
methodsIn our method, change of the signal intensity between the pretreatment and follow-up hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was calculated and then threshold dose (TD) for developing FLR was obtained from correlation of dose with the change of the signal intensity. For validation of the method, TDs for six patients, who had been treated for liver cancer with SABR with 45-60 Gy in 3 fractions, were calculated using the method, and we evaluated concordance between volume enclosed by isodose of TD by the method and volume identified as FLR by a physician.
resultsThe dose to normal liver was correlated with change in signal intensity between pretreatment and follow-up MRI with a median R(2) of 0.935 (range, 0.748 to 0.985). The median TD by the method was 23.5 Gy (range, 18.3 to 39.4 Gy). The median value of concordance was 84.5% (range, 44.7% to 95.9%).
conclusionOur method is capable of providing a quantitative evaluation of the relationship between dose and intensity changes on follow-up MRI, as well as determining individual TD for developing FLR. We expect our method to provide better information about the individual relationship between dose and FLR in radiotherapy for liver cancer.
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