ArticleJournal of circadian rhythms2016
A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women.
Article in Journal of circadian rhythms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- New Insights into Health Conditions Related to Malfunctions in Clock Genes.Biomolecules · 2024Article
- The influence of PER3 VNTR genotypes on the age of onset in a group of bipolar I disorder patients: an exploratory study.International journal of bipolar disorders · 2024Article
- Article
- Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy.Scientific reports · 2021Article
- Chronotype and Mental Health: Recent Advances.Current psychiatry reports · 2018Review
- Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort.Sleep medicine · 2018Article
- Daytime Sleep Disturbance in Night Shift Work and the Role ofJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Human genetics and sleep behavior.Current opinion in neurobiology · 2017Review
- Associations between period 3 gene polymorphisms and sleep- /chronotype-related variables in patients with late-life insomnia.Chronobiology international · 2017Article
- Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus.International journal of endocrinology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExpression of the clock family of genes in the suprachiasmatic nuclei (SCN) regulates the molecular control of circadian timing. Increasing evidence also implicates clock gene activity in the development of mood disorders. In particular, variation in the PER3 clock gene has been shown to influence diurnal preference and sleep homeostasis. However, there is not currently a clear association between PER3 polymorphisms and mood. This is possibly because the PER3 gene has been shown to influence homeostatic sleep drive, rather than circadian timing, and the PER3 gene may be behaviorally relevant only under chronic sleep loss conditions.
methodsTo test the association between PER3 allele status and impaired mood, a total of 205 healthy women were genotyped for PER3 allele status and responded to previously-validated psychological questionnaires surveying self-reported sleep habits (MEQ, PSQI) and mood. Our mood measures included two measures of short-term, transient mood (state anxiety and mood disturbance) and two measures of longer term, ongoing mood (trait anxiety and depressive symptomology).
resultsThe PER3 genotype distribution was 88 (42.9%) for PER3(4/4), 98 (47.8%) for PER3(4/5), and 19 (9.3%) for PER3(5/5). Our sleep duration x genotype interaction analyses showed that, relative to longer allele carriers, PER3(4/4) genotypes were at greater risk for transient psychological effects (mood and state anxiety) when they reported reduced sleep durations.
conclusionSleep duration plays a critical role in understanding the extent to which PER3 allele status relates to mood states.
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