Evidence map›Paper›PMID 27103883›Full record

ArticleDose-response : a publication of International Hormesis Society

Treatment of Alzheimer Disease With CT Scans: A Case Report.

Jerry M Cuttler, Eugene R Moore, Victor D Hosfeld, David L Nadolski

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03597360 (Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia), which is not on this map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03597360 nacompletednot on this map

Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia (LDIR-CT-AD) Trial: A Pilot Study

TypeinterventionalSponsorBaycrestRan2019 to 2020Enrolled4ConditionsDementia AlzheimersArmsCT scan
3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jerry M CuttlerCuttler & Associates Inc, Ontario, Canada.
Eugene R MooreDow Chemical Company, Midland, MI, USA.
Victor D HosfeldMidMichigan Health, Midland, MI, USA.
David L NadolskiMidland Internal Medicine Associates PC, Midland, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 computed tomography scans of the brain, about 40 mGy each, over a period of 3 months. The mechanism appears to be radiation-induced upregulation of the patient's adaptive protection systems against AD, which partially restored cognition, memory, speech, movement, and appetite.

Indexed as

adaptive protection systemsAlzheimer diseaseCT scanionizing radiation

Identifiers

PMID27103883
PMCPMC4826954

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.