ArticleTurk pediatri arsivi2016
Neurological features and management of Wilson disease in children: an evaluation of 12 cases.
Article in Turk pediatri arsivi, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Comprehensive Assessment of Reflux Burden and Mucosal Integrity in Children: Insights from MNBI and Impedance-pH Monitoring.Children (Basel, Switzerland) · 2025Article
- Brain MRI in the Decision for Liver Transplantation in Pediatric Neurological Wilson's Disease.Movement disorders clinical practice · 2022Article
- Neurological features and outcomes of Wilson's disease: a single-center experience.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Mental Health, Cognitive, and Neuropsychiatric Needs in Children and Young People With Wilson Disease.JPGN reports · 2021Article
- Psychological Signs as the Only Presentation of Wilson's Disease in an 11-Year-Old Boy.Iranian journal of child neurology · 2018Article
- Medical treatment of dystonia.Journal of clinical movement disorders · 2016Review
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Abstract
aimWilson's disease is an autosomal recessive disorder of copper metabolism which leads to copper overload in different tissues of the body. The aim of this study was to present the neurologic features of Wilson's disease and to assess the clinical course of neurological findings in children receiving anti-copper treatment. MATERIAL AND
methodsTwelve children with a diagnosis of Wilson's disease and findings of central nervous system involvement who were followed up in the Department of Pediatric Neurology and Pediatric Gastroenterology of the School of Medicine at Erciyes University were enrolled in the study.
resultsThe study cases consisted of five boys (42%) and seven girls (58%). The mean age at the time of diagnosis was 9.9±3.4 years (5-15 years). The mean duration of follow-up was 49.0±36.4 months (15-128 months). Neurological findings at presentation included headache in seven cases (58%), tremor in seven cases (58%), dystonia in three cases (25%), ataxia in two cases (17%), dizziness in two cases (17%), numbness in the hands and acute weakness in one case (8%) and syncope in one case (8%). Headache, dizziness, syncope, numbness in hands and acute weakness symptoms resolved completely within six months after receiving treatment. Movement disorders either decreased or remained stable in seven of the eight cases. However, one patient developed progressively worsening dystonia despite to all treatments.
conclusionsWilson's disease can be manifested with signs and symptoms of central nervous system in the childhood. Wilson's disease should be considered in all children presenting with movement disorders. A complete neurological assessment should be carried out in all cases with Wilson's disease.
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