Evidence map›Paper›PMID 27103770›Full record

ArticleEthnicity & disease2016

Sex and Race Differences in the Relationship between Obesity and C-Reactive Protein.

Daniel O Clark, Kathleen T Unroe, Huiping Xu, NiCole R Keith, Christopher M Callahan, Wanzhu Tu

Open access · bronzeAbstract read
In one paragraph

Article in Ethnicity & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Daniel O ClarkIndiana University Center for Aging Research, Indianapolis, Indiana; Regenstrief Institute, Inc., Indianapolis, Indiana.
Kathleen T UnroeIndiana University Center for Aging Research, Indianapolis, Indiana.
Huiping XuDepartment of Biostatistics, Indiana University.
NiCole R KeithRegenstrief Institute, Inc., Indianapolis, Indiana.
Christopher M CallahanRegenstrief Institute, Inc., Indianapolis, Indiana.
Wanzhu TuDepartment of Biostatistics, Indiana University.
Indiana University · USIndiana University – Purdue University Indianapolis · USRegenstrief Institute · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
TRANSLATION RESEARCH ON CHRONIC DISEASE SELF-MANAGEMENTP30AG024967 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CALLAHAN, CHRISTOPHER M · 2004 to 2013
$3.2M
RCT of Video-Conference & In-Person Weight Loss Services for Adult CHC PatientsR01DK092377 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI CLARK, DANIEL O · 2012 to 2015
$1.9M
MODELING ALZHEIMER DISEASE COSTS AND TRANSITIONSR01AG031222 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI CALLAHAN, CHRISTOPHER M · 2009 to 2010
$1.3M
NCATS NIH HHS UL1 TR001108NIA NIH HHS P30 AG024967NIA NIH HHS R01 AG031222NIA NIH HHS U01 AG009740NIDDK NIH HHS R01 DK092377
6 · The paper itself

Abstract

C-reactive protein (CRP) is a risk factor for cardiovascular disease and mortality; it is known to be positively associated with obesity but there is some evidence that this association differs by race or sex. We used nationally representative data of adults aged >50 years to investigate sex and race modifiers of the associations between obesity and CRP in non-Hispanic White males (n=3,517) and females (n=4,658), and non-Hispanic Black males (n=464) and females (n=826). Using multiple linear regression models with the natural logarithm of CRP as the dependent variable, we sequentially included body mass index (BMI), a body shape index (ABSI), and socioeconomic, health and health behavior covariates in the model. The association between BMI and CRP was significantly stronger in females than males. Obese White females had mean CRP values slightly above 3 mg/liter (vs 2 for White males) and Black females had mean CRP values >4 mg/liter (vs 3 for Black males). More than 50% of Black females in the United States have obesity. Continued research into racial and sex differences in the relationship between obesity, inflammation, and health risks may ultimately lead to more personalized weight loss recommendations.

Indexed as

AdultAgedBlack or African AmericanBody Mass IndexCardiovascular DiseasesC-Reactive ProteinEthnicityFemaleHealth BehaviorHumansInflammationMaleMiddle AgedObesityRacial GroupsRisk FactorsC-Reactive ProteinAgedC-reactive proteinObesityRaceSex Differences

Identifiers

PMID27103770
PMCPMC4836900
OpenAlexW2341679633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.