ArticleBMC neurology2016
Increase in national intravenous thrombolysis rates for ischaemic stroke between 2005 and 2012: is bigger better?
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Cluster-Randomized Trial of Thrombolysis Implementation Support in Metropolitan and Regional Australian Stroke Centers: Lessons for Individual and Systems Behavior Change.Journal of the American Heart Association · 2020Trial
- Door-to-needle time for thrombolysis: a secondary analysis of the TIPS cluster randomised controlled trial.BMJ open · 2019Trial
- Knowledge, Attitude, and Practice of Thrombolysis in Family Members of Cerebral Infarction Patients: Structural Equation Modeling Analysis.International journal of general medicine · 2026Article
- The impact of a comprehensive national policy on improving acute stroke patient care in Lithuania.European stroke journal · 2022Article
- Rates of intravenous thrombolysis and endovascular therapy for acute ischaemic stroke in China between 2019 and 2020.The Lancet regional health. Western Pacific · 2022Article
- Epidemiological analysis of stroke patients with emphasis on access to acute-phase therapies.Arquivos de neuro-psiquiatria · 2022Article
- Temporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019: Modeling Based on Joinpoint Regression.Frontiers in neurology · 2022Article
- Implementation of a provincial acute stroke pathway and its impact on access to advanced stroke care in Saskatchewan.BMJ open quality · 2021Article
- Coagulation markers and functional outcome in acute ischemic stroke: Impact of intensive versus standard hyperglycemia control.Research and practice in thrombosis and haemostasis · 2021Article
- Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke.Oxidative medicine and cellular longevity · 2021Article
- Factors Affecting Pre-Hospital and In-Hospital Delays in Treatment of Ischemic Stroke; a Prospective Cohort Study.Archives of academic emergency medicine · 2021Article
- Routing to Endovascular Treatment of Ischemic Stroke in Korea: Recognition of Need for Process Improvement.Journal of Korean medical science · 2020Article
- Assessment of eligibility for thrombolysis in acute ischaemic stroke patients in Morocco.The Pan African medical journal · 2020Article
- Can clinical audits be enhanced by pathway simulation and machine learning? An example from the acute stroke pathway.BMJ open · 2019Article
- Intravenous thrombolytic therapy for acute ischemic stroke in Hubei, China: a survey of thrombolysis rate and barriers.BMC neurology · 2019Article
- Management of acute ischemic stroke, thrombolysis rate, and predictors of clinical outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society.Journal of stroke · 2019 · on this mapArticle
- Thrombolysis for stroke in Ireland: increasing access and maintaining safety in a challenging environment.Irish journal of medical science · 2018Article
- Acute Ischemic Stroke Hospital Admissions, Treatment, and Outcomes in Poland in 2009-2013.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntravenous thrombolytic therapy after ischaemic stroke significantly reduces mortality and morbidity. Actual thrombolysis rates are disappointingly low in many western countries. It has been suggested that higher patient volume is related to shorter door-to-needle-time (DNT) and increased thrombolysis rates. We address a twofold research question: a) What are trends in national thrombolysis rates and door-to-needle times in the Netherlands between 2005-2012? and b) Is there a relationship between stroke patient volume per hospital, thrombolysis rates and DNT?
methodsWe used data from the Stroke Knowledge Network Netherlands dataset. Information on volume, intravenous thrombolysis rates, and admission characteristics per hospital is acquired through yearly surveys, in up to 65 hospitals between January 2005 and December 2012. We used linear regression to determine a possible relationship between hospital stroke admission volume, hospital thrombolysis rates and mean hospital DNT, adjusted for patient characteristics.
resultsInformation on 121.887 stroke admissions was available, ranging from 7.393 admissions in 2005 to 24.067 admissions in 2012. Mean national thrombolysis rate increased from 6.4% in 2005 to 14.6% in 2012. Patient characteristics (mean age, gender, type of stroke) remained stable. Mean DNT decreased from 72.7 min in 2005 to 41.4 min in 2012. Volume of stroke admissions was not an independent predictor for mean thrombolysis rate nor for mean DNT.
conclusionIntravenous thrombolysis rates in the Netherlands more than doubled between 2005 and 2012, in parallel with a large decline in mean DNT. We found no convincing evidence for a relationship between stroke patient volume per hospital and thrombolysis rate or DNT.
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